Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
- Abstract
- BACKGROUND/AIMS: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). METHODS: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. RESULTS: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. CONCLUSIONS: Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
- All Author(s)
- J. H. Lee
; M. H. Oh
; J. S. Park
; G. J. Na
; H. W. Gil
; J. O. Yang
; E. Y. Lee
; S. Y. Hong
- Issued Date
- 2014
- Type
- Article
- Keyword
- Glomerulonephritis, IGA; Plasminogen activator inhibitor 1; Urokinase-type plasminogen activator; Receptors, urokinase plasminogen activator
- Publisher
- 대한내과학회
- ISSN
- 1226-3303
; 2005-6648
- Citation Title
- The Korean journal of internal medicine
- Citation Volume
- 29
- Citation Number
- 2
- Citation Start Page
- 176
- Citation End Page
- 182
- Language(ISO)
- eng
- DOI
- 10.3904/kjim.2014.29.2.176
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/962
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