Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis
- Abstract
- BACKGROUND: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19). RESULTS: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0.01 and p = 0.0001, respectively), NSIP (p = 4.95E - 7 and p = 0.0002, respectively), HP (p = 0.00003 and p = 0.000005, respectively), and sarcoidosis groups (p = 0.003 and p = 0.0001, respectively). However, the IL-25 levels were not significantly different between NC and IPF group (p = 0.432). Receiver operating characteristic curves of the TSLP and IL-33 levels revealed clear differences between the IPF and NC groups (AUC = 0.655 and 0.706, respectively), as well as between the IPF and the other lung disease groups (AUC = 0.786 and 0.781, respectively). Cut-off values of 3.52pg/μg TSLP and 3.77pg/μg IL-33 were shown to differentiate between the IPF and NC groups with 99.2 and 94.3% accuracy. Cut-off values of 4.66pg/μg TSLP and 2.52pg/μg IL-33 possessed 99.4 and 93.2% accuracy for differentiating among the IPF and other interstitial lung disease groups. CONCLUSIONS: Innate immune responses may be associated with the development of IPF. Furthermore, the IL-33 and TSLP levels in BAL fluids may be useful for differentiating IPF from other chronic interstitial lung diseases.
- All Author(s)
- J. U. Lee
; H. S. Chang
; H. J. Lee
; C. A. Jung
; D. J. Bae
; H. J. Song
; J. S. Park
; S. T. Uh
; Y. H. Kim
; K. H. Seo
; C. S. Park
- Issued Date
- 2017
- Type
- Article
- Keyword
- IL-25; IL-33; TSLP; IPF; Innate immune response
- Publisher
- BioMed Central
- ISSN
- 1471-2466
- Citation Title
- BMC pulmonary medicine
- Citation Volume
- 17
- Citation Number
- 1
- Citation Start Page
- 39
- Citation End Page
- 39
- Language(ISO)
- eng
- DOI
- 10.1186/s12890-017-0380-z
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/952
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