Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy
- Abstract
- OBJECTIVE: To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy. METHODS: This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0-10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and transrectal ultrasound examination. BMI was grouped according to the Asia-Pacific obesity criteria: nonobese (<25 kg/m(2)) versus obese (≥ 25 kg/m(2)). Partial correlation and linear regression models between PSA, PSAD and BMI were conducted after adjusting for age. RESULTS: A total of 907 men were enrolled in this study. On multivariate analyses, PSA showed no significant correlation with age or BMI, whereas PSAD had a negative correlation with age and BMI. Similar results were obtained when patients were categorized as having low (3.0 < PSA ≤ 6.5 ng/ml) or high PSA (6.5 < PSA ≤ 10.0 ng/ml) levels. CONCLUSION: PSAD, but not PSA, demonstrated a significant negative correlation with BMI. This indicates that a new strategy including PSAD rather than simple PSA levels should be adopted in the study of obesity-adjusted PSA cut-offs.
- All Author(s)
- J. H. Kim
; S. W. Lee
; H. J. Yang
; S. W. Doo
; J. H. Yoon
; D. S. Kim
; W. J. Yang
; K. W. Lee
; J. M. Kim
; C. Lee
; S. S. Kwon
- Issued Date
- 2014
- Type
- Article
- Keyword
- Prostate-specific antigen; rostate-specific antigen density; body mass index
- ISSN
- 0300-0605
- Citation Title
- Journal of International Medical Research
- Citation Volume
- 42
- Citation Number
- 3
- Citation Start Page
- 821
- Citation End Page
- 827
- Language(ISO)
- eng
- DOI
- 10.1177/0300060513518038
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/891
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