Appropriate Number of Adjuvant Chemotherapy Cycles for Patients with Stage 2 or 3 Gastric Cancer After Curative Gastrectomy: A Multicenter Cohort Study
- Abstract
- BACKGROUND: Few studies have presented evidence pertaining to the adequate minimum number of adjuvant chemotherapy (AC) cycles required to achieve an oncologic benefit for gastric cancer. METHODS: From January 2012 to December 2013, data from patients who underwent curative radical gastrectomy and consequently received AC for pathologic stage 2 or 3 gastric cancer at 27 institutions in South Korea were analyzed. RESULTS: The study enrolled 925 patients, 661 patients (71.5%) who completed 8 cycles of AC and 264 patients (28.5%) who did not. Compared with the mean disease-free survival (DFS) of the patients who completed 8 AC cycles (69.3months), the mean DFS of patients who completed 6 AC cycles (72.4months; p = 0.531) and those who completed 7 AC cycles (63.7months; p = 0.184) did not differ significantly. However, the mean DFS of the patients who completed 5 AC cycles (48.2months; p = 0.016) and those who completed 1-4 AC cycles (62.9months; p = 0.036) was significantly lower than the DFS of those who completed 8 AC cycles. In the multivariate Cox proportional hazards analysis, the mean DFS was significantly affected by advanced stage, large tumor size, positive vascular invasion, and number of completed AC cycles (1-5 cycles: hazard ratio 1.45; 95% confidence interval 1.01-2.08; p = 0.041). CONCLUSION: The current multicenter observational cohort study showed that the mean DFS for 6 or 7 AC cycles was similar to that for 8 AC cycles as an adjuvant treatment for gastric cancer.
- All Author(s)
- S. H. Jeong
; M. W. Yoo
; Y. G. Son
; S. J. Oh
; J. H. Kim
; H. I. Kim
; J. M. Park
; H. Hur
; Y. S. Jee
; S. H. Hwang
; S. H. Jin
; S. E. Lee
; Y. J. Lee
; K. W. Seo
; S. Park
; C. M. Lee
; C. H. Kim
; I. H. Jeong
; H. H. Lee
; S. I. Choi
; S. I. Lee
; C. Y. Kim
; H. Chae
; M. W. Son
; K. H. Pak
; S. Kim
; M. S. Lee
; J. S. Min
- Issued Date
- 2021
- Type
- Article
- Keyword
- Antineoplastic Combined Chemotherapy; Protocols/therapeutic use; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Gastrectomy; Humans; Neoplasm Staging; Republic of Korea; Retrospective Studies; *Stomach Neoplasms/drug therapy/surgery
- ISSN
- 1068-9265
- Citation Title
- Annals of Surgical Oncology
- Citation Volume
- 28
- Citation Number
- 8
- Citation Start Page
- 4458
- Citation End Page
- 4470
- Language(ISO)
- eng
- DOI
- 10.1245/s10434-020-09504-4
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/825
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