The angiography-guided spot versus entire stenting in patients with long coronary lesions trial: Study design and rationale for a randomized controlled trial protocol
- Abstract
- BACKGROUND: /Purpose: Long-stenting, even with a second-generation drug-eluting stent (DES), is an independent predictor of restenosis and stent thrombosis in patients with long coronary lesions. Spot-stenting, i.e., selective stenting of only the most severe stenotic segments of a long lesion, may be an alternative to a DES. The purpose of this study is to compare the one-year clinical outcomes of patients with spot versus entire stenting in long coronary lesions using a second-generation DES. METHOD: This study is a randomized, prospective, multi-center trial comparing long-term clinical outcomes of angiography-guided spot versus entire stenting in patients with long coronary lesions (≥25mm in length). The primary endpoint is target vessel failure (TVF) at 12 months, a composite of cardiac death, target vessel-related myocardial infarction, and target vessel revascularization (TVR). A total of 470 patients are enrolled for this study according to sample size calculations. This study will be conducted to evaluate the non-inferiority of spot stenting compared to entire stenting with zotarolimus-eluting stents (ZES). RESULTS: This study is designed to evaluate the clinical impact of spot-stenting with ZESs for TVF due to possible edge restenosis or non-target lesion revascularization. Theoretically, spot-stenting may decrease the risk of TVR and the extent of endothelial dysfunction. CONCLUSION: This SPOT trial will provide clinical insight into spot-stenting with a current second-generation DES as a new strategy for long coronary lesions.
- All Author(s)
- J. Y. Baek
; S. W. Rha
; B. G. Choi
; C. U. Choi
; K. H. Park
; B. H. Hwang
; S. J. Lee
; Y. K. Ahn
; J. W. Choi
; I. H. Chae
; W. H. Choi
; Y. H. Lim
; J. H. Ahn
; W. G. Choi
- Issued Date
- 2020
- Type
- Article
- Keyword
- Long coronary lesion; Percutaneous coronary intervention; Spot stenting
- ISSN
- 2451-8654
- Citation Title
- Contemporary Clinical Trials Communications
- Citation Volume
- 17
- Citation Start Page
- 100523
- Citation End Page
- 100523
- Language(ISO)
- eng
- DOI
- 10.1016/j.conctc.2020.100523
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/774
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