An Analysis of the proteomics approach to the glycated peptides of human milk
- Abstract
- Many studies have shown that advanced glycation end-products (AGEs) and glycation adducts are significantly linked to aging and disease. Particularly, the level of glycation in human milk is important because the AGE intake is closely related to AGE levels in infants. In this study, we used human milk samples obtained from four primiparae and four multiparae. We isolated proteins using acetone and trichloroacetic acid (TCA) precipitation. A total of 67 glycated proteins and 122 glycated peptides was quantified; among them, 19 glycated peptides were differentially expressed. We confirmed that the degree of glycation differed according to fertility. The study provides a foundation for using proteomics to evaluate the mother's milk quality and link between maternal health and human milk quality.
- All Author(s)
- S. Cho
; J.-M. Park
; H. Lee
; J. H. Song
; N. M. Kang
- Issued Date
- 2022
- Type
- Article
- Keyword
- glycation; advanced glycation end-product; human milk; LC-MS/MS; fertility
- Publisher
- 한국분석과학회
- ISSN
- 1225-0163
- Citation Title
- Analytical Science & Technology
- Citation Volume
- 35
- Citation Number
- 1
- Citation Start Page
- 8
- Citation End Page
- 14
- Language(ISO)
- eng
- DOI
- 10.5806/AST.2022.35.1.8
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/740
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.