Aldose Reductase Inhibitor Ameliorates Renal Vascular Endothelial Growth Factor Expression in Streptozotocin-Induced Diabetic Rats
- Abstract
- PURPOSE: The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of aldose reductase inhibitor, fidarestat on diabetic nephropathy, and renal VEGF expression in a type 1 diabetic rat model. MATERIALS AND METHODS: Twenty four Sprague-Dawley male rats which were performed intraperitoneal injection of streptozotocin and normal six rats were divided into four groups including a normal control group, untreated diabetic control group, aldose reductase (AR) inhibitor (fidarestat, 16 mg.kg(-1).day(-1)) treated diabetic group, and angiotensin receptor blocker (losartan, 20 mg.kg(-1).day(-1)) treated diabetic group. We checked body weights and blood glucose levels monthly and measured urine albumin-creatinine ratio (ACR) at 8 and 32 weeks. We extracted the kidney to examine the renal morphology and VEGF expressions. RESULTS: The ACR decreased in fidarestat and losartan treated diabetic rat groups than in untreated diabetic group (24.79 +/- 11.12, 16.11 +/- 9.95, and 84.85 +/- 91.19, p < 0.05). The renal VEGF messenger RNA (mRNA) and protein expression were significantly decreased in the fidarestat and losartan treated diabetic rat groups than in the diabetic control group. CONCLUSION: We suggested that aldose reductase inhibitor may have preventive effect on diabetic nephropathy by reducing renal VEGF overexpression.
- All Author(s)
- J. K. Sung
; J. H. Koh
; M. Y. Lee
; B. H. Kim
; S. M. Nam
; J. H. Kim
; J. H. Yoo
; S. H. Kim
; S. W. Hong
; E. Y. Lee
; R. Choi
; C. H. Chung
- Issued Date
- 2010
- Type
- Article
- Keyword
- Aldose reductase inhibitor; vascular endothelial growth factor; albumin creatinine ratio; diabetic nephropathy
- ISSN
- 0513-5796
- Citation Title
- Yonsei Medical Journal
- Citation Volume
- 51
- Citation Number
- 3
- Citation Start Page
- 385
- Citation End Page
- 391
- Language(ISO)
- eng
- DOI
- 10.3349/ymj.2010.51.3.385
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/698
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