항정신병 약물과 혈당조절이상
- Alternative Title
- Antipsychotics and Abnormality in Glucose Regulation
- Abstract
- Objective:The purpose of this study was to know about the mechanism of pathogenesis of type 2 diabetes mellitus by using of blood glucose, glucoregulatory factor, insulin resistance in schizophrenic patients receiving antipsychotics. Method:Modified oral glucose tolerance tests were performed in 20 schizophrenic patients receiving haloperidol, risperidone and olanzapine. Insulin, glucagon, C-peptide and cortisol were measured in 0, 15, 45, 75 minutes after glucose loading, and insulin resistance was calculated by HOMA(homeostasis model assessment) method. Result:Olanzapine-treated patients had significant glucose elevation 45 minutes after glucose challenge. Also modest increases in HOMA IR values were detected in patients treated with olanzapine. Conclusion:Olanzapine treatment of non-diabetic patients with schizophrenia can be associated with type 2 diabetes mellitus through the elevation of glucose and insulin resistance. Elevated insulin resistance may be a causative mechanism of type 2 diabetes mellitus in patients receiving olanzapine.
- All Author(s)
- 황재승
; 김현
; 권영준
; 정희연
- Issued Date
- 2003
- Type
- Article
- Keyword
- Antipsychotics; Blood glucose; Insulin resistance
- Publisher
- 대한생물정신의학회
- ISSN
- 1225-8709
; 2005-7571
- Citation Title
- 생물정신의학
Korean Journal of Biological Psychiatry
- Citation Volume
- 10
- Citation Number
- 2
- Citation Start Page
- 107
- Citation End Page
- 115
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/605
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