정신분열병의 CDH2 유전자 다형성
- Alternative Title
- The CDH2 Gene Polymorphism in Schizophrenia
- Abstract
- Objective:There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia. Methods:Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls. Results:No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene. Conclusion:The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.
- All Author(s)
- 이원석
; 김미경
; 정한용
; 우성일
; 권영준
; 김종우
; 이희제
- Issued Date
- 2005
- Type
- Article
- Keyword
- CDH2; Polymorphism; Schizophrenia
- Publisher
- 대한생물정신의학회
- ISSN
- 1225-8709
; 2005-7571
- Citation Title
- 생물정신의학
Korean Journal of Biological Psychiatry
- Citation Volume
- 12
- Citation Number
- 1
- Citation Start Page
- 62
- Citation End Page
- 67
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/552
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