Retinal Crystal-like Deposits after Topical Pranoprofen Administration in Anterior Uveitis Patient

Abstract

Purpose: To report the case of a patient with anterior uveitis who presented accumulation of multiple crystal-like deposits on the retinal surface without vitritis sign or visual disturbance following topical non-steroidal anti-inflammatory drug (NSAID) use. Case summary: A 61-year-old man used pranoprofen, a topical NSAID, to treat recurrent anterior uveitis accompanied by suspicious steroid-induced glaucoma. After application of topical NSAID, intraocular pressure was controlled, and he did not experience visual disturbance. After one month of topical NSAID use, multiple yellow-green-colored glistering crystal-like deposits were identified on the macular area without signs of vitritis. Additionally, optical coherence tomography imaging revealed highly reflective deposits on the retinal surface. After three months of drug cessation, the number of deposits markedly decreased without additional retinal morbidity, and re-accumulation of crystal-like deposits was absent for two years. Conclusions: Accumulation of multiple retinal deposits with crystal-like morphology on the macular area could be observed after application of topical NSAIDs without vitritis sign and visual disturbance symptom. The deposits resolved spontaneously following cessation of topical agent administration.