Prognostic Value of Dual-Time-Point [(18)F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer
- Abstract
- This study aimed to evaluate the prognostic significance of 2-Deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed DTP [(18)F]FDG PET/CT images from 211 patients with NSCLC. The maximum standardized uptake value (SUV) of primary lung cancer and mean [(18)F]FDG uptake of the BM (BM SUV) were measured from early and delayed PET/CT images, and the percent changes in these parameters (∆maximum SUV and ∆BM SUV) were calculated. On multivariate survival analysis, the maximum SUV and BM SUV on both early and delayed PET/CT scans were significantly associated with PFS, while the ∆maximum SUV and ∆BM SUV failed to show statistical significance. For DMFS, the ∆maximum SUV and ∆BM SUV were independent predictors along with the TNM stage. Distant progression was observed only in 1.3% of patients with low ∆maximum SUV and ∆BM SUV, whereas 28.2% of patients with high ∆maximum SUV and ∆BM SUV experienced distant progression. The ∆maximum SUV and ∆BM SUV on DTP [(18)F]FDG PET/CT were significant independent predictors for DMFS in patients with NSCLC.
- All Author(s)
- S. M. Lee
; J. W. Lee
; J. H. Lee
; I. Y. Jo
; S. J. Jang
- Intsitutional Author(s)
- 이상미; 조인영
- Issued Date
- 2022
- Type
- Article
- Keyword
- bone marrow; fluorodeoxyglucose F-18; non-small cell lung cancer; positron emission tomography; prognosis
- Publisher
- MDPI
- ISSN
- 2075-4426
- Citation Title
- Journal of personalized medicine
- Citation Volume
- 12
- Citation Number
- 4
- Citation Start Page
- 592
- Citation End Page
- 592
- Language(ISO)
- eng
- DOI
- 10.3390/jpm12040592
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3591
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