Risk of dementia in survivors of active tuberculosis in Korea: A nationwide cohort study
- Abstract
- Background: Concern has been growing regarding post-tuberculosis (TB) morbidities, including neurologic and vascular comorbidities. However, the association between post-TB status and the risk of dementia has been evaluated in only few studies. Therefore, in the present study, the risk of dementia was investigated in a nationwide population-based cohort.
Methods: Using the Korean National Health Insurance Service (KNHIS) database, this study included TB survivors (n = 50,182) and matched controls (n = 50,182) for age, sex, and year of index date. The risk of dementia was estimated using Cox proportional hazards regression, and stratified analyses for related factors were performed.
Results: During a mean 3.5 years of follow-up, the incidence of dementia was 9.32 for Alzheimer disease and 1.17 for vascular dementia per 1000 person-years for TB survivors and 7.21 and 0.67, respectively, for matched controls. The overall risk of Alzheimer disease was 1.11 (95% confidence interval (CI) 1.03-1.20)-fold higher in TB survivors than in matched controls. For vascular dementia, 1.48 (95% CI 1.16-1.89)-fold higher risk was found in TB survivors than in matched controls. The strength of the association between TB and dementia was higher in CNS TB (aHR 1.76, 95% CI 1.18 -2.64) than non-CNS TB (aHR 1.11, 95% CI 1.05-1.19) compared to controls, especially for patients with vascular dementia (3.33, 95% CI 1.06-10.49).
Conclusion: TB survivors had a significantly higher risk of dementia than the general population.
- All Author(s)
- Yohwan Yeo
; Jung Eun Yoo
; Kyungdo Han
; Jin-Hyung Jung
; Hayoung Choi
; Jongkyu Park
; Dong Wook Shin
; Hyun Lee
- Issued Date
- 2024
- Type
- Article
- Keyword
- Alzheimer disease; Pulmonary tuberculosis; Vascular dementia
- Publisher
- King Saud Bin Abdulaziz University for Health Sciences
- ISSN
- 1876-0341
; 1876-035X
- Citation Title
- Journal of infection and public health
- Citation Volume
- 17
- Citation Number
- 2
- Citation Start Page
- 286
- Citation End Page
- 292
- Language(ISO)
- eng
- DOI
- 10.1016/j.jiph.2023.12.006
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3409
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