The impact of sex differences on 3-year outcomes of patients with non-ST-segment elevation myocardial infarction after successful stent implantation according to symptom-to-balloon time
- Abstract
- Background: Because no data are available, we compared the 3-year outcomes of patients with non-ST-elevation myocardial infarction (NSTEMI) based on sex and symptom-to-balloon time (SBT).
Methods: This study included 4910 patients who were divided into two groups based on SBT: SBT <48 h (n = 3,293, 67.1%) and SBT ≥48 h (n = 1,617, 32.9%). The primary outcome was all-cause death during the 3-year follow-up period. The secondary outcome was major adverse cardiac events (MACE), defined as all-cause death, recurrent myocardial infarction, or repeat coronary revascularization.
Results: After adjustment, the in-hospital mortality rates for males and females in the SBT <48 h and SBT ≥48 h groups were similar. During a 3-year follow-up period, females in the SBT <48 h group had significantly higher rates of all-cause death (adjusted hazard ratio [aHR], 1.482; P = 0.006), cardiac death (CD, aHR, 1.617; P = 0.009), and MACE (aHR, 1.268; P = 0.024) than those males in the same groups. Females and males in the SBT ≥48 h group did not differ significantly in the primary and secondary outcomes. In males, the rates of all-cause death (P = 0.008) and CD (P = 0.024) were significantly higher in the SBT ≥48 h group than in the SBT <48 h group.
Conclusions: This study has identified a higher 3-year mortality rate in female patients with NSTEMI and SBT <48 h compared to their male counterparts. As such, a more preventive approach may be required to reduce mortality in these female patients.
- All Author(s)
- Yong Hoon Kim
; Ae-Young Her
; Seung-Woon Rha
; Cheol Ung Choi
; Byoung Geol Choi
; Soohyung Park
; Dong Oh Kang
; Jung Rae Cho
; Ji Young Park
; Sang-Ho Park
; Myung Ho Jeong
- Issued Date
- 2023
- Type
- Article
- Keyword
- Mortality; Non-ST Elevated Myocardial Infarction; Percutaneous Coronary Intervention; Sex Factors
- Publisher
- Elsevier B.V.
- ISSN
- 1109-9666
; 2241-5955
- Citation Title
- Hellenic journal of cardiology
- Language(ISO)
- eng
- DOI
- 10.1016/j.hjc.2023.09.018
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3366
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