Three-Year Clinical Outcomes Based on Pre-Percutaneous Coronary Intervention Coronary Blood Flow Grade and Symptom-to-Balloon Time in Patients with Non-ST-Segment Elevation Myocardial Infarction
- Abstract
- We compared the 3-year clinical outcomes according to the degree of pre-percutaneous coronary intervention thrombolysis in myocardial infarction flow grade (pre-PCI TIMI) and symptom-to-balloon time (SBT) individuals who underwent successful stent implantation with a diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI). A total of 4910 patients with NSTEMI were divided into two groups: pre-PCI TIMI 0/1 (SBT < 48 h: n = 1328, SBT ≥ 48 h: n = 558) and pre-PCI TIMI 2/3 (SBT < 48 h: n = 1965, SBT ≥ 48 h: n = 1059). The primary outcome was a 3-year all-cause death rate, and the secondary outcome was the composite endpoint of 3-year all-cause death, recurrent MI, or any repeat revascularization rate. After adjustment, in the pre-PCI TIMI 0/1 group, the 3-year all-cause death (p = 0.003), cardiac death (CD, p < 0.001), and secondary outcome (p = 0.030) values were significantly higher in the SBT ≥ 48 h group than in the SBT < 48 h group. However, patients with pre-PCI TIMI 2/3 had similar primary and secondary outcomes, regardless of the SBT group. Within the SBT < 48 h group, the pre-PCI TIMI 2/3 group exhibited significantly higher rates of 3-year all-cause death, CD, recurrent MI, and secondary outcome values than the pre-PCI TIMI 0/1 group. Patients in the SBT ≥ 48 h group with either pre-PCI TIMI 0/1 or TIMI 2/3 had similar primary and secondary outcomes. Our results suggest that shortening the SBT may confer a survival benefit in patients with NSTEMI and those in the pre-PCI TIMI 0/1 group compared to those in the pre-PCI TIMI 2/3 group.
- All Author(s)
- Yong Hoon Kim
; Ae-Young Her
; Seung-Woon Rha
; Cheol Ung Choi
; Byoung Geol Choi
; Soohyung Park
; Dong Oh Kang
; Jung Rae Cho
; Ji Young Park
; Sang-Ho Park
; Myung Ho Jeong
- Issued Date
- 2023
- Type
- Article
- Keyword
- non-ST-segment elevation myocardial infarction; percutaneous coronary intervention; reperfusion
- Publisher
- MDPI
- ISSN
- 2077-0383
- Citation Title
- Journal of clinical medicine
- Citation Volume
- 12
- Citation Number
- 11
- Citation Start Page
- 3654
- Citation End Page
- 3654
- Language(ISO)
- eng
- DOI
- 10.3390/jcm12113654
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3364
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