Predictive Factors for Sustained Remission after Discontinuation of Antiviral Therapy in Patients with HBeAg-positive Chronic Hepatitis B
- Alternative Title
- HBeAg 양성 만성간염 환자에서 항바이러스 치료 중단 후 지속적인 관해에 대한 예측 인자
- Abstract
- BACKGROUND/AIMS: The optimal timing for discontinuing oral antiviral therapy in patients with HBeAg-positive chronic hepatitis B (CHB) is unclear. The aim of our study was to investigate sustained remission after stopping antiviral therapy in patients with HBeAg-positive CHB. METHODS: We analyzed the medical records of 58 patients who were HBeAg-positive and had discontinued antiviral therapy. Antiviral therapy was discontinued after HBeAg seroconversion and HBV DNA negativity for 6-12 months with consolidation therapy. Virologic relapse was defined as an increase in serum HBV DNA >2,000 IU/mL. RESULTS: No difference was observed between the virologic non-relapse and virologic relapse groups in baseline HBV DNA level (p=0.441) or duration of seroconversion (p=0.070). Time-to-undetectable HBV DNA during treatment was shorter in the virologic non-relapse group (29 patients) compared to the relapse group (29 patients) (4.9±2.6 vs. 13.2±12.7 months; p<0.01). Cumulative relapse rates were 12.7 in month 3, 32.7 in month 6, 47.3 in month 12, and 52.7% in month 18. We determined by multivariate analysis that the consolidation period (≥18 months, p=0.020) and early virologic response (HBV DNA <20 IU/mL) at six months during antiviral therapy (p=0.017) were significant predictors for sustained remission. CONCLUSIONS: A consolidation period of at least 18 months and early virological response at six months during antiviral therapy were associated with sustained remission in patients with HBeAg-positive CHB after treatment.
- All Author(s)
- B. G. Jun
; S. H. Lee
; H. S. Kim
; S. G. Kim
; Y. S. Kim
; B. S. Kim
; S. W. Jeong
; J. Y. Jang
; Y. D. Kim
; G. J. Cheon
- Issued Date
- 2016
- Type
- Article
- Keyword
- Treatment; Chronic hepatitis B; Discontinuation; Remission; Relapse
- Publisher
- 대한소화기학회
The Korean Society of Gastroenterology
- ISSN
- 1598-9992
; 2233-6869
- Citation Title
- 대한소화기학회지
The Korean Journal of Gastroenterology
- Citation Volume
- 67
- Citation Number
- 1
- Citation Start Page
- 28
- Citation End Page
- 34
- Language(ISO)
- eng
- DOI
- 10.4166/kjg.2016.67.1.28
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3177
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