후천성 멜라닌세포성 모반의 bcl-2와 PCNA발현에 관한 면역조직화학적 연구
- Alternative Title
- Immunohistochemical Expression of bcl-2 and PCNA in Acquired Melanocytic Nevi
- Abstract
- BACKGROUND: The histogenesis of acquired melanocytic nevi is still a matter of debate. One considers that nevus cells originate from epidermal melanocytes and the other postulates that nevus cells are of both neural and melanocytic origin. OBJECTIVE: To clarify this controversy, investigation of the growth dynamics and tissue homeostasis of nevi is needed. METHODS: We compared expressions for PCNA and bcl-2 in 12 intradermal nevi and 8 compound nevi by immunohistochemical staining. RESULTS: The results are summarizid as follows: 1. bcl-2 : Both intradermal and compound nevi exhibited strong perinuclear and cytoplasmic staining. There was diminution of staining with progressive descent into the dermis. 2. PCNA : The mean rate of PCNA-positive nevus cells was higher in compound nevi than in intradermal nevi. CONCLUSION: The findings of our study shows considerable differences between intradermal nevi and compound nevi in expressions for PCNA and bcl-2.
- All Author(s)
- T. J. Kim
; S. Y. Lee
; J. S. Lee
; K. U. Whang
- Issued Date
- 2002
- Type
- Article
- Keyword
- Acquired melanocytic nevi; bcl-2; PCNA
- Publisher
- 대한피부과학회
Korean Dermatological Association
- ISSN
- 0494-4739
; 2713-7627
- Citation Title
- 대한피부과학회지
Korean Journal of Dermatology
- Citation Volume
- 40
- Citation Number
- 11
- Citation Start Page
- 1325
- Citation End Page
- 1331
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3137
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