심근경색증 환자에서 아포 E 지단백유전자의 다형성
- Alternative Title
- Apolipoprotein E Polymorphism in Patients with Myocardial Infarction
- Abstract
- Background and Objectives
In this study we investigated the association between the polymorphism of apolipoprotein E and the development of myocardial infarction, and assessed whether this polymorphism produces any changes of plasma lipid level.
Subjects and Methods
A total of 182 patients participated in this study and were divided into two groups; 91 patients with myocardial infarction (MI group) and 91 patients with no known heart disease (control group). For both groups we analyzed the clinical parameters, the changes of plasma lipid level and the degree of polymorphism of apolipoprotein E.
Results
Total cholesterol, triglyceride and LDL cholesterol levels were significantly higher in the MI group, while the HDL cholesterol level was significantly lower. Compared with the control group, the frequency of epsilon2 allele was significantly lower while that of epsilon3 allele was significantly higher in the MI group. As for the control group, the triglyceride level was significantly higher in the patients with epsilon 2 allele than in those without epsilon 2 allele, and the total cholesterol level was significantly higher in the patients with epsilon 4 allele than in those without epsilon 4 allele. In the MI group, the plasma lipid levels were not significantly different from those in the control group.
Conclusion
We suggested that apolipoprotein E polymorphism could affect the lipid metabolism as well as the development of myocardial infarction. However further study is needed in patients with myocardial infarction.
- All Author(s)
- H. S. Jeong
; S. K. Kim
; S. C. Lee
; D. W. Bang
; W. Y. Shin
; Y. K. On
; S. C. Choe
; C. H. Kim
; T. M. Choi
; M. S. Hyun
; E. S. Jeon
; Y. J. Kwon
- Issued Date
- 2002
- Type
- Article
- Keyword
- Myocardial infarction; Apolipoproteins E; Lipids; Lipoproteins
- Publisher
- 대한심장학회
Korean Society of Cardiology
- ISSN
- 1225-164X
- Citation Title
- 순환기
The Korean circulation journal
- Citation Volume
- 32
- Citation Number
- 1
- Citation Start Page
- 31
- Citation End Page
- 37
- Language(ISO)
- kor
- DOI
- 10.4070/kcj.2002.32.1.31
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3043
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.