Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls
- Abstract
- This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = -0.46, p = .000), SD in weight (r = -0.32, p = .005), Tanner stage (r = -0.41, p = .000), and bone age (r = -0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation.
- All Author(s)
- H. R. Jeong
; H. J. Lee
; Y. S. Shim
; M. J. Kang
; S. Yang
; I. T. Hwang
- Issued Date
- 2019
- Type
- Article
- Keyword
- Precocious puberty; MKRN3; biomarker
- Publisher
- International Society of Gynecological Endocrinology
- ISSN
- 0951-3590
- Citation Title
- Gynecological Endocrinology
- Citation Volume
- 35
- Citation Number
- 8
- Citation Start Page
- 732
- Citation End Page
- 736
- Language(ISO)
- eng
- DOI
- 10.1080/09513590.2019.1576615
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2990
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