Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma
- Abstract
- BACKGROUND/AIMS: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). METHODS: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). RESULTS: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p<0.001), respectively. Elevated serum α-fetoprotein (AFP) (>20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p<0.001), respectively. Tumor size (>5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS. CONCLUSIONS: In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.
- All Author(s)
- S. O. Jeong
; E. B. Kim
; S. W. Jeong
; J. Y. Jang
; S. H. Lee
; S. G. Kim
; S. W. Cha
; Y. S. Kim
; Y. D. Cho
; H. S. Kim
; B. S. Kim
; Y. J. Kim
; D. E. Goo
; S. Y. Park
- Issued Date
- 2017
- Type
- Article
- Keyword
- Carcinoma; hepatocellular; Chemoembolization; therapeutic; Complete response; Recurrence
- Publisher
- 대한소화기학회
- ISSN
- 1976-2283
- Citation Title
- Gut and Liver
- Citation Volume
- 11
- Citation Number
- 3
- Citation Start Page
- 409
- Citation End Page
- 416
- Language(ISO)
- eng
- DOI
- 10.5009/gnl16001
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2980
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