Prophylactic temporary 3F pancreatic duct stent to prevent post-ERCP pancreatitis in patients with a difficult biliary cannulation: a multicenter, prospective, randomized study
- Abstract
- Background: Post-ERCP pancreatitis (PEP) is the most common and serious complication of ERCP. Difficult biliary cannulation can be a procedure-related risk factor for PEP. Recent studies reported that a prophylactic pancreatic stent (PS) can reduce the frequency and severity of PEP. Objective: To evaluate the efficacy and usefulness of a temporary 3F PS to prevent PEP in patients with difficult biliary cannulations. Design: A multicenter, prospective, randomized study. Setting: Two tertiary-care academic medical centers. Patients: In total, 101 patients with a difficult biliary cannulation were randomly divided into the 3F PS placement group (PS group, n = 50) or the nonstent (NS) group (NS group, n = 51). Interventions: Endoscopic placement of a 3F unflanged PS. Main Outcome Measurements: The incidence and severity of PEP in the 2 groups, spontaneous dislodgment of stents, and procedure-related complications. Results: The technical success rate of 3F PS placement was 96% (48/50). The lengths of the stents were 4 cm (n = 21), 6 cm (n = 15), and 8 cm (n = 12). Spontaneous stent dislodgment within 7 days occurred in 94% of patients (45/48). The mean duration until spontaneous dislodgment was 3.5 days. The incidence rate of PEP was 12% (6/50: mild, 5; moderate, 1) in the PS group and 29.4% (15/51: mild, 12; moderate, 2; severe, 1) in the NS group. Severe pancreatitis occurred in only 1 patient in the NS group. In a multivariate analysis, prophylactic placement of PS was the only prophylactic factor for PEP (odds ratio, 0.126; 95% CI, 0.025-0.632, P = .012). Limitations: No comparative results for stent size and diameter and a low-risk cohort group. Conclusions: Prophylactic temporary 3F PS placement in patients with a difficult biliary cannulation during ERCP seems to be a safe and effective method for reducing PEP and results in a high rate of spontaneous passage of stents without complications. (Gastrointest Endosc 2012;76:578-85.)
- All Author(s)
- T. H. Lee
; J. H. Moon
; H. J. Choi
; S. H. Han
; Y. K. Cheon
; Y. D. Cho
; S. H. Park
; S. J. Kim
- Issued Date
- 2012
- Type
- Article
- Keyword
- retrograde cholangiopancreatography pancreatitis; sphincterotomy-induced; pancreatitis; oddi dysfunction; placement; risk; complications; metaanalysis; obstruction; removal; reduce
- Publisher
- American Society for Gastrointestinal Endoscopy
- ISSN
- 0016-5107
- Citation Title
- Gastrointestinal Endoscopy
- Citation Volume
- 76
- Citation Number
- 3
- Citation Start Page
- 578
- Citation End Page
- 585
- Language(ISO)
- eng
- DOI
- 10.1016/j.gie.2012.05.001
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2810
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.