Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
- Abstract
- Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation.
- All Author(s)
- R. Choi
; B. H. Kim
; J. Naowaboot
; M. Y. Lee
; M. R. Hyun
; E. J. Cho
; E. S. Lee
; E. Y. Lee
; Y. C. Yang
; C. H. Chung
- Issued Date
- 2011
- Type
- Article
- Keyword
- diabetes mellitus, experimental; diabetic nephropathies; ferulic acid; inflammation; oxidative stress
- Publisher
- 생화학분자생물학회
- ISSN
- 1226-3613
- Citation Title
- Experimental & Molecular Medicine
- Citation Volume
- 43
- Citation Number
- 12
- Citation Start Page
- 676
- Citation End Page
- 683
- Language(ISO)
- eng
- DOI
- 10.3858/emm.2011.43.12.078
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2660
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