Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty, liver disease in Koreans
- Abstract
- Background The pathogenesis of fatty liver is likely to depend on a complex interaction of environmental and genetic factors. We investigated a large-scale analysis of the association between microsomal triglyceride transfer protein (MTTP) and phosphatidylethanolamine N-methyltransferase (PEMT) polymorphism in alcoholic and nonalcoholic fatty liver disease. Methods Five hundred and eighty-eight patients who visited the health promotion center were enrolled. To elucidate the possible role of genetic variation affecting triglyceride metabolism in fatty liver disease, the MTTP-I128T and PEMT-V175M polymorphisms were studied. Results The I/I genotype and I allele frequency of MTTP polymorphism with alcoholic fatty liver was significantly higher than that of the normal control group (P=0.026 vs. 0.005). Genotype and allele frequency of PEMT, however, did not show a significant difference between control and fatty liver. I/I genotype of MTTP gene frequency in the drinkers with fatty livers was 85.4%, which was significantly higher than that in the drinkers without fatty liver, which was 68.4% (P=0.013). With regard to biochemical indicators, the alanine aminotransferase value of the I/I group was significantly higher than that of the I/T and T/T groups (P=0.04). Asparate aminotransferase, gamma-glutamyl transpeptidase, triglyceride, apolipoprotein B, and glucose concentration tended to be lower in the I/T and T/T groups than in the I/I group, but no statistically significant difference was found. Conclusion In this study, MTTP-I128T polymorphism is associated with central obesity, elevated liver enzymes, and alcoholic fatty liver disease. Eur J Gastroenterol Hepatol 21:667-672 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
- All Author(s)
- D. W. Jun
; J. H. Han
; E. C. Jang
; S. H. Kim
; Y. J. Jo
; Y. S. Park
; J. D. Chae
- Issued Date
- 2009
- Type
- Article
- Keyword
- alcoholic fatty liver; microsomal triglyceride transfer protein; nonalcholic fatty liver; polymorphism
- ISSN
- 0954-691X
- Citation Title
- European Journal of Gastroenterology & Hepatology
- Citation Volume
- 21
- Citation Number
- 6
- Citation Start Page
- 667
- Citation End Page
- 672
- Language(ISO)
- eng
- DOI
- 10.1097/MEG.0b013e3283196adc
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2651
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