Gender differences in seizure recurrence and antiepileptic drug polytherapy predicting health-related quality of life of persons 1 year after diagnosis of epilepsy
- Abstract
- PURPOSE: The aim of this study was to determine whether gender influences the prediction of health-related quality of life (HRQoL) in persons with newly diagnosed epilepsy (NDE). METHODS: This was a 1-year longitudinal study. Persons with NDE were assessed with the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), the Hospital Anxiety Depression Scale (HADS), the Stigma Scale, and the Rosenberg Self-esteem Scale. An analysis of covariance (ANCOVA) with interaction terms was used. RESULTS: Among 134 adults with NDE, there were no gender differences in the scores of the QOLIE-31 and its subscales. A multivariate linear regression analysis showed that the HADS-anxiety scores at diagnosis (p = 0.005) and seizure recurrence after diagnosis (p = 0.050) negatively predicted QOLIE-31 scores in persons with NDE. There were significant effects of the gender interaction with seizure recurrence (F = 8.745, p = 0.004, partial eta(2) = 0.066) and antiepileptic drug (AED) polytherapy (F = 6.320, p = 0.013, partial eta(2) = 0.049) in the adjusted model. Specifically, seizure recurrence negatively predicted the QOLIE-31 scores only in men. By contrast, AED polytherapy negatively predicted the QOLIE-31 scores only in women. CONCLUSIONS: There are gender differences in certain epilepsy-related factors predicting HRQoL at 1 year in persons with NDE.
- All Author(s)
- S. A. Lee
; S. J. Kim
; S. K. No
; H. K. Park
; O. J. Kim
- Issued Date
- 2021
- Type
- Article
- Keyword
- Epilepsy; Newly diagnosed epilepsy; Health-related quality of life; Antiepileptic drug polytherapy; Seizure recurrence; Anxiety
- ISSN
- 1525-5050
- Citation Title
- Epilepsy & Behavior
- Citation Volume
- 120
- Citation Start Page
- 107984
- Citation End Page
- 107984
- Language(ISO)
- eng
- DOI
- 10.1016/j.yebeh.2021.107984
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2621
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