Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer
- Abstract
- This study aimed to investigate the clinical outcomes of intensity-modulated radiotherapy (IMRT)-based stereotactic body radiotherapy (SBRT) for patients with stage I non-small cell lung cancer (NSCLC). A prospective database of 16 consecutive patients receiving SBRT for pathologically-proven and peripherally-located stage I NSCLC was reviewed. Fifteen patients were medically inoperable and one patient refused to undergo surgery. The median age of the patients was 76 years (range, 69-86). Treatment planning used four-dimensional computed tomography and fixed-field IMRT (n=11) or volumetric-modulated arc therapy (V MAT; n=5). The SBRT scheme was 48 Gy in four fractions (n=9) or 55 Gy in five fractions (n=7), delivered on consecutive days. The overall response rate at 6 months was 78.6%, including a complete response in three (21.4%) patients and a partial response in eight (57.1%). Three patients (21.4%) demonstrated a stable disease status. The median follow-up time was 14 months (range, 6-20) for the surviving patients. One patient developed local failure at 11 months, while another suffered from regional failure in a subcarinal lymph node at 4 months. Two patients did not survive within the first 6 months; one patient died during salvage chemotherapy for mediastinal lymph node metastasis and the other succumbed to a cause unrelated to lung cancer. The Kaplan-Meier estimates of local failure-free, progression-free and overall survival rates at 18 months were 91.0, 85.2 and 87.5%, respectively. The toxicity was mild; no severe (grade >= 3) toxicity was identified. IMRT-based (including VMAT) delivery of SBRT for patients with stage I NSCLC demonstrated favorable responses and local control without severe toxicity.
- All Author(s)
- M. J. Kim
; S. G. Yeo
; E. S. Kim
; C. K. Min
; P. Sean
- Intsitutional Author(s)
- 김은석
- Issued Date
- 2013
- Type
- Article
- Keyword
- non-small cell lung cancer; medically inoperable, stage I; stereotactic body radiotherapy; intensity-modulated radiotherapy
- Publisher
- Spandidos Publications
- ISSN
- 1792-1074
; 1792-1082
- Citation Title
- Oncology letters
- Citation Volume
- 5
- Citation Number
- 3
- Citation Start Page
- 840
- Citation End Page
- 844
- Language(ISO)
- eng
- DOI
- 10.3892/ol.2012.1082
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2557
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