Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status?
- Abstract
- Background: Neuromyelitis optica spectrum disorder (NMOSD) targets astrocytes and elevates the levels of astrocyte-injury markers during attacks. FAM19A5, involved in reactive gliosis, is secreted by reactive astrocytes following central nervous system (CNS) damage.
Objective: To investigate the significance of serum FAM19A5 in patients with NMOSD.
Methods: We collected clinical data and sera of 199 patients from 11 hospitals over 21 months. FAM19A5 levels were compared among three groups: NMOSD with positive anti-aquaporin-4 antibody (NMOSD-AQP4), other CNS demyelinating disease, and healthy controls.
Results: The median serum FAM19A5 level was higher in the NMOSD-AQP4 (4.90 ng/mL (3.95, 5.79)) than in the other CNS demyelinating (2.35 ng/mL (1.83, 4.07), p < 0.001) or healthy control (1.02 ng/mL (0.92, 1.14), p < 0.001) groups. There were significant differences in the median serum FAM19A5 levels between the attack and remission periods (5.89 ng/mL (5.18, 6.98); 4.40 ng/mL (2.72, 5.13), p < 0.001) in the NMOSD-AQP4 group. Sampling during an attack (p < 0.001) and number of past attacks (p = 0.010) were independently associated with increased serum FAM19A5.
Conclusion: Serum FAM19A5 was higher in patients with NMOSD-AQP4 and correlated with clinical characteristics. Thus, serum FAM19A5 may be a novel clinical biomarker for NMOSD-AQP4.
- All Author(s)
- H. L. Lee
; H. Y. Seok
; H. W. Ryu
; E. B. Cho
; B. C. Kim
; B. J. Kim
; J. H. Min
; J. M. Seok
; H. Y. Shin
; S. Y. Kang
; O. H. Kwon
; S. S. Lee
; J. Oh
; E. H. Sohn
; S. Y. Huh
; J. Y. Cho
; J. Y. Seong
- Issued Date
- 2020
- Type
- Article
- Keyword
- CNS demyelinating disease; FAM19A5; MOG associated disease; Neuromyelitis optica spectrum disorder; astrocyte; reactive gliosis
- Publisher
- SAGE Publications
- ISSN
- 1352-4585
; 1477-0970
- Citation Title
- Multiple sclerosis : clinical and laboratory research
- Citation Volume
- 26
- Citation Number
- 13
- Citation Start Page
- 1700
- Citation End Page
- 1707
- Language(ISO)
- eng
- DOI
- 10.1177/1352458519885489
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2486
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