Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea
- Abstract
- Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea.
Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone.
Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.
- All Author(s)
- K. H. Song
; E. S. Kim
; K. H. Park
; H. J. Choi
; K. H. Kim
; S. Lee
; J. H. Hwang
; E. J. Choo
; Y. Park
; E. J. Lee
; Y. K. Kim
; M. H. Jeon
; C. Moon
; J. S. Park
; K. U. Park
; P. G. Choe
; J. H. Bang
; M. D. Oh
; H. B. Kim
- Issued Date
- 2019
- Type
- Article
- Keyword
- Panton–Valentine leukocidin; molecular epidemiology
- Publisher
- Mary Ann Liebert
- ISSN
- 1076-6294
; 1931-8448
- Citation Title
- Microbial drug resistance
- Citation Volume
- 25
- Citation Number
- 3
- Citation Start Page
- 450
- Citation End Page
- 456
- Language(ISO)
- eng
- DOI
- 10.1089/mdr.2018.0238
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2459
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