The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
- Abstract
- Background: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular
endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated
increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically
assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC).
Methods: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June
2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship
between HDGF expression and clinical outcome in patients with NSCLC.
Results: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75–2.76, P<.001) and 2.77
(95% CI 1.79–4.29, P<.001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly
correlated with a larger tumor size (OR 1.59, 95% CI 1.02–2.46, P=.040).
Conclusion: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC.
- All Author(s)
- H. M. Koh
; C. L. Hyun
; B. G. Jang
; H. J. Lee
- Issued Date
- 2020
- Type
- Article
- Keyword
- hepatoma-derived growth factor; meta-analysis; non-small cell lung cancer; prognosis
- Publisher
- Lippincott Williams & Wilkins
- ISSN
- 0025-7974
; 1536-5964
- Citation Title
- Medicine
- Citation Volume
- 99
- Citation Number
- 51
- Citation Start Page
- e23837
- Citation End Page
- e23837
- Language(ISO)
- eng
- DOI
- 10.1097/md.0000000000023837
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2445
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