Evaluation of the efficacy of 1 L polyethylene glycol plus ascorbic acid and an oral sodium sulfate solution: A multi-center, prospective randomized controlled trial
- Abstract
- Introduction: Low-volume bowel preparation has been developed to increase patient compliance. We compared 1 L of
polyethylene glycol/ascorbic acid (PEG/Asc) and oral sodium sulfate (OSS) with respect to bowel preparation efficacy, compliance,
and safety.
Methods: A multicenter, prospective, randomized, single-blinded, non-inferiority trial was conducted in 3 hospitals. Patients
were randomized to receive a bowel-cleansing agent. Bowel-cleansing efficacy was evaluated using the Boston Bowel
Preparation Scale (BBPS). Satisfaction, feeling, taste of the bowel cleanser, and adverse events after taking the bowel cleanser
were investigated through a questionnaire. Additionally, blood samples were analyzed before and after bowel cleansing.
Results: In total, 172 patients were analyzed (85 with 1 L PEG/Asc and 87 with OSS), and the mean BBPS scores were
comparable between agents. The 1L PEG/Asc group tended to have a higher BBPS score in the right colon (2.22 vs 2.02;
P = .08). The compliance of 1 L of PEG/Asc was comparable to that of OSS. Patients taking 1 L PEG/Asc reported greater thirst
and dizziness (P = .04 and P = .047, respectively) than the OSS cohort. On the other hand, gastrointestinal symptoms such as
vomiting and abdominal distension were more common in the OSS group, without statistical significance. In terms of laboratory
adverse events, elevation of serum creatinine was found in both groups after taking the bowel cleansing agent (P < .001 for the 1L
PEG/Asc group; P = .04 for the OSS group). However, most of the increased values were within the normal ranges.
Discussion: The 1L PEG/Asc treatment was comparable to OSS in terms of bowel preparation efficacy, compliance, and safety
- All Author(s)
- J. H. Woo
; H. S. Koo
; D. S. Kim
; J. E. Shin
; Y. Jung
; K. C. Huh
- Issued Date
- 2022
- Type
- Article
- Keyword
- cathartics; colonoscopy; polyethylene glycols; sodium sulfate
- Publisher
- Lippincott Williams & Wilkins
- ISSN
- 0025-7974
; 1536-5964
- Citation Title
- Medicine
- Citation Volume
- 101
- Citation Number
- 35
- Citation Start Page
- e30355
- Citation End Page
- e30355
- Language(ISO)
- eng
- DOI
- 10.1097/md.0000000000030355
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2427
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