Cognitive decline according to amyloid uptake in patients with poststroke cognitive impairment
- Abstract
- Background and purpose: Poststroke cognitive impairment (PSCI) is common, but the impact of b-amyloid (Ab) on PSCI is
uncertain. The proposed study will investigate amyloid pathology in participants with PSCI and how differently their cognition
progress according to the amyloid pathology.
Methods: This multicenter study was designed to be prospective and observational based on a projected cohort size of 196
participants with either newly developed cognitive impairment, or rapidly aggravated CI, within 3 months after acute cerebral
infarction. They will undergo 18F-flutemetamol positron emission tomography at baseline and will be categorized as either amyloidpositive (A+) or amyloid-negative (A) by visual rating. The primary outcome measures will be based on Korean Mini-Mental State
Examination changes (baseline to 12months) between the A+ and A groups. The secondary outcome measures will be the
dementia-conversion rate and changes in the Korean version of the Montreal Cognitive Assessment (baseline to 12months) between
the A+ and A groups.
Conclusions: This study will provide a broadened perspective on the impact of Ab on the cause and outcomes of PSCI in clinical
practice. Identifying amyloid pathology in patients with PSCI will help select patients who need more focused treatments such as
acetylcholinesterase inhibitors
Trial registration: Clinical Research Information Service identifier: KCT0005086
- All Author(s)
- B. Yoon
; D. W. Yang
; Y. J. Hong
; T. Kim
; S. Na
; S. M. Noh
; H. L. Park
; B. D. Ku
; Y. S. Yang
; H. Choi
; J. W. Jang
; S. Kim
; Y. Kim
; Y. Shim
- Issued Date
- 2021
- Type
- Article
- Keyword
- amyloid; cerebral infarct; clinical trial; cognitive impairment; prognosis
- Publisher
- Lippincott Williams & Wilkins
- ISSN
- 0025-7974
; 1536-5964
- Citation Title
- Medicine
- Citation Volume
- 100
- Citation Number
- 38
- Citation Start Page
- e27252
- Citation End Page
- e27252
- Language(ISO)
- eng
- DOI
- 10.1097/md.0000000000027252
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2417
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