Dioscorea batatas extract attenuates high-fat diet-induced obesity in mice by decreasing expression of inflammatory cytokines
- Abstract
- Background: The objective of the present study was to determine whether Dioscorea batatas (DB) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD) and whether genes associated with adipogenesis and inflammation could be modulated by a diet containing DB extract.
Material and methods: Male C57BL/6J mice were divided into 4 groups (n=10 per group): normal diet (ND), HFD, 100 mg/kg DB extract-gavage with HFD, and 200 mg/kg DB extract-gavage with HFD. The mice were fed the experimental diets for 14 weeks. At 12 weeks, micro-computed X-ray tomography (micro-CT) was performed.
Results: Supplementation of the diet with DB extract for 14 weeks significantly prevented HFD-induced increases in body weight, visceral adipose tissue, plasma lipid levels, and leptins. The area of visceral fat was reduced by DB extract supplementation when examined by micro-CT. Supplementation with DB extract resulted in the downregulation of the adipogenic transcription factor (C/ERBa) and its target gene (CD36) in epididymal adipose tissue, compared to HFD alone. DB extract decreased the expression of proinflammatory cytokines (TNF-α, MCP-1, and IL-6) in epididymal adipose tissue.
Conclusions: Our results suggest that DB extract may prevent HFD-induced obesity by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.
- All Author(s)
- H. W. Gil
; E. Y. Lee
; J. H. Lee
; Y. S. Kim
; B. E. Lee
; J. W. Suk
; H. Y. Song
- Issued Date
- 2015
- Type
- Article
- Keyword
- Adipogenesis; Diet, High-Fat; Dioscorea; Obesity
- Publisher
- International Scientific Information, Inc
- ISSN
- 1234-1010
; 1643-3750
- Citation Title
- Medical science monitor
- Citation Volume
- 21
- Citation Start Page
- 489
- Citation End Page
- 495
- Language(ISO)
- eng
- DOI
- 10.12659/msm.891306
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2392
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