Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
- Abstract
- Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis-alkynyl pyridines that shows a strong anti-angiogenic activity. In the present study, we examined the effect of dietary supplementation with Cur2004-8 on response to environmental stresses and aging using Caenorhabditis elegans as a model system. Dietary intervention with Cur2004-8 significantly increased resistance of C. elegans to oxidative stress. Its anti-oxidative-stress effect was greater than curcumin. However, response of C. elegans to heat stress or ultraviolet irradiation was not significantly affected by Cur2004-8. Next, we examined the effect of Cur2004-8 on aging. Cur2004-8 significantly extended both mean and maximum lifespan, accompanying a shift in time-course distribution of progeny production. Age-related decline in motility was also delayed by supplementation with Cur2004-8. In addition, Cur2004-8 prevented amyloid-beta-induced toxicity in Alzheimer's disease model animals which required a forkhead box (FOXO) transcription factor DAF-16. Dietary supplementation with Cur2004-8 also reversed the increase of mortality observed in worms treated with high-glucose-diet. These results suggest that Cur2004-8 has higher anti-oxidant and anti-aging activities than curcumin. It can be used for the development of novel anti-aging product.
- All Author(s)
- B. K. Kim
; S. A. Kim
; S. M. Baek
; E. Y. Lee
; E. S. Lee
; C. H. Chung
; C. M. Ahn
; S. K. Park
- Issued Date
- 2019
- Type
- Article
- Keyword
- Curcumin; Cur2004-8; oxidative stress; aging; Caenorhabditis elegans
- ISSN
- 1881-7831
- Citation Title
- Drug Discoveries & Therapeutics
- Citation Volume
- 13
- Citation Number
- 4
- Citation Start Page
- 198
- Citation End Page
- 206
- Language(ISO)
- eng
- DOI
- 10.5582/ddt.2019.01057
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2317
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.