Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study
- Abstract
- Clopidogrel is the mainstay for antiplatelet treatment after percutaneous coronary intervention (PCI). The relationship of platelet reactivity and genetic polymorphism with clinical outcomes with newer-generation drug-eluting stents is unclear. We analysed 4,587 patients for the most powerful single-nucleotide polymorphisms (CYP2C19, CYP2C9, ABCB1, PON1, and P2Y12) related to on-treatment platelet reactivity (OPR). The optimal cut-off value of high OPR for major adverse thrombotic events was 266. CYP2C19 was significantly associated with high OPR and the number of CYP2C19*R (*2 or *3) alleles was proportional to the increased risk of high OPR. Death, myocardial infarction (MI), stroke, stent thrombosis, and bleeding events were assessed during a 1-year follow-up period. Primary endpoints were death and non-fatal MI. The cumulative 1-year incidence of death and stent thrombosis was significantly higher in patients with CYP2C19*2/*2, CYP2C19*2/*3, and CYP2C19*3/*3 (Group 3) than in patients with CYP2C19*1/*1 (Group 1). Multivariate Cox proportional hazard model showed that cardiac death risk was significantly higher in Group 3 than in Group 1 (hazard ratio 2.69, 95% confidence interval 1.154-6.263, p = 0.022). No association was reported between bleeding and OPR. Thus, CYP2C19 may exert a significant impact on the prognosis of PCI patients even in the era of newer-generation drug-eluting stents.
- All Author(s)
- H. J. Joo
; S. G. Ahn
; J. H. Park
; J. Y. Park
; S. J. Hong
; S. Y. Kim
; W. Choi
; H. Gwon
; Y. H. Lim
; W. Kim
; W. C. Kang
; Y. H. Cho
; Y. H. Kim
; J. Yoon
; W. Shin
; M. K. Hong
; S. Garg
; Y. Jang
; D. S. Lim
- Issued Date
- 2018
- Type
- Article
- Publisher
- Nature Publishing Group
- ISSN
- 2045-2322
- Citation Title
- Scientific reports
- Citation Volume
- 8
- Citation Number
- 1
- Citation Start Page
- 1229
- Citation End Page
- 1229
- Language(ISO)
- eng
- DOI
- 10.1038/s41598-017-18134-y
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2113
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