Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study
- Abstract
- Objectives: To compare the efficacy of rescue therapies in lamivudine (LAM)-resistant chronic hepatitis B (CHB) infections including: (1) adefovir dipivoxil (ADV) monotherapy, (2) ADV plus LAM combination therapy and (3) entecavir (ETV) 1.0 mg monotherapy.
Materials and methods: The authors designed a multicenter-retrospective study. Eight institutions participated in the study from Korea.
Results: A total of 343 LAM-resistant CHB patients were enrolled. The proportion of patients with undetectable serum hepatitis B virus (HBV) DNA levels at month 24 after the initiation of rescue therapy was higher in the ADV plus LAM combination therapy group (39/64, 60.9%) than in the ADV monotherapy (50/126, 39.7%) and ETV 1.0 mg monotherapy (19/48, 39.6%) groups (p = 0.014). Mean serum HBV DNA levels at 24 months were 2.07 ± 1.21 log(10) IU/ml in the ADV plus LAM combination therapy group, 2.74 ± 1.74 log(10) IU/ml in the ADV monotherapy group and 3.08 ± 1.97 log(10) IU/ml in the ETV 1.0 mg monotherapy group (p = 0.014). In multivariate analysis, a finding of undetectable serum HBV DNA level at 6 months and ADV plus LAM combination therapy (vs. ADV) was an independent factor for predicting undetectable serum HBV DNA at month 24 (odds ratio, 1.003; 95% confidence interval, 1.000-1.006; p = 0.026).
Conclusions: ADV plus LAM combination therapy is more effective in reducing viral load than switching to ADV or ETV 1.0 mg in patients with LAM-resistant CHB.
- All Author(s)
- S. J. Lee
; H. J. Yim
; S. G. Hwang
; Y. S. Seo
; J. H. Kim
; E. L. Yoon
; J. M. Lee
; B. H. Kim
; S. J. Park
; Y. M. Park
; H. S. Kim
; S. H. Lee
; S. H. Ahn
; J. I. Lee
; J. W. Lee
; I. H. Kim
; S. P. Hong
- Issued Date
- 2013
- Type
- Article
- Keyword
- adefovir; antiviral resistance; chronic hepatitis B; combination drug therapy; entecavir; lamivudine; multicenter study
- Publisher
- Informa Healthcare
- ISSN
- 0036-5521
; 1502-7708
- Citation Title
- Scandinavian Journal of Gastroenterology
- Citation Volume
- 48
- Citation Number
- 2
- Citation Start Page
- 196
- Citation End Page
- 204
- Language(ISO)
- eng
- DOI
- 10.3109/00365521.2012.722671
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2103
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