Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes
- Abstract
- Objective
Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated. Therefore, this study evaluated whether plasma and urinary α-klotho levels are associated with albuminuria in kidney disease in diabetes.
Research Design and Methods
A total of 147 patients with type 2 diabetes and 25 healthy control subjects were enrolled. The plasma and urine concentrations of α-klotho were analyzed by enzyme-linked immunosorbent assay.
Results
Plasma α-klotho (572.4 pg/mL [95% CI, 541.9–604.6 pg/mL] vs. 476.9 pg/mL [95% CI, 416.9–545.5 pg/mL]) and urinary α-klotho levels (59.8 pg/mg creatinine [95% CI, 43.6–82.0 pg/mg creatinine] vs. 21.0 pg/mg creatinine [95% CI, 9.7–45.6 pg/mg creatinine]) were significantly higher in diabetic patients than non-diabetic controls. Among diabetic patients, plasma α-klotho concentration was inversely associated with albuminuria stages (normoalbuminuria, 612.6 pg/mL [95% CI, 568.9–659.6 pg/mL], microalbuminuria, 551.8 pg/mL [95% CI, 500.5–608.3 pg/mL], and macroalbuminuria, 505.7 pg/mL [95% CI, 439.7–581.7 pg/mL] (p for trend = 0.0081), while urinary α-klotho levels were remained constantly high with increasing urinary albumin excretion.
Conclusions
Soluble α-klotho levels in plasma and urine may be novel and useful early markers of diabetic renal injury.
- All Author(s)
- E. Y. Lee
; S. S. Kim
; J. S. Lee
; I. J. Kim
; S. H. Song
; S. K. Cha
; K. S. Park
; J. S. Kang
; C. H. Chung
- Issued Date
- 2014
- Type
- Article
- Publisher
- Public Library of Science
- ISSN
- 1932-6203
- Citation Title
- PloS one
- Citation Volume
- 9
- Citation Number
- 8
- Citation Start Page
- e0102984
- Citation End Page
- e0102984
- Language(ISO)
- eng
- DOI
- 10.1371/journal.pone.0102984
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2039
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