Safety and Efficacy of a New Moldable and Compression Resistant Matrix Carrier with Recombinant Human Bone Morphogenetic Protein-2 in the Rabbit Bone Defect Model
- Abstract
- AIM: To conduct an animal experimental study to evaluate the safety and efficacy of the compression-resistant matrix (CRM) carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) in osteogenesis. MATERIAL AND METHODS: New moldable CRM carrier, and with rhBMP-2 (new CRM carrier with rhBMP-2) were prepared as the experimental groups. Pre-existing synthetic bone graft material was prepared as a control graft group. A total of 24 rabbits were included in the study. Defects were made and grafts were performed, and radiographic and histopathologic findings were evaluated to assess fusion. RESULTS: In the computed tomographic scan, new bone formation was superior in 16.0%, 39.3%, 64.7%, and 81.1% of the total defect volume at 4, 8, 12, and 16 weeks in the new CRM carrier with rhBMP-2 group. In the new CRM carrier group, new bone formation was observed in 10.6%, 26.3%, 53.1%, and 71.4%, respectively. In the control graft group, new bone formation was observed in 10.1%, 26.6%, 53.4%, and 72.1%, respectively. On histopathologic evaluation, new CRM carrier with rhBMP-2 group showed better new bone formation compared with those of other groups. CONCLUSION: The new moldable CRM carrier and the CRM carrier with rhBMP-2 showed preclinical safety and efficacy in new bone formation. In particular, the CRM carrier with rhBMP-2 was considered to be an effective bone graft material for bone fusion.
- All Author(s)
- J. M. Ahn
; S. J. Hyun
; K. J. Kim
- Issued Date
- 2022
- Type
- Article
- Keyword
- rhBMP-2; Compression resistant matrix; Pseudarthrosis; Hydroxyapatite; Tricalcium phosphate
- Publisher
- Türk Nöroşirürji Derneǧi
- ISSN
- 1019-5149
; 2651-5032
- Citation Title
- Turkish neurosurgery
- Citation Volume
- 32
- Citation Number
- 5
- Citation Start Page
- 845
- Citation End Page
- 853
- Language(ISO)
- eng
- DOI
- 10.5137/1019-5149.Jtn.37422-21.2
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1941
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