CXCR3 expression as a prognostic factor in gastric cancer: a meta-analysis
- Abstract
- BACKGROUND: CXC chemokine receptor 3 (CXCR3) plays a critical role in tumorigenesis, and CXCR3 expression is associated with prognosis in many cancers. Recently, CXCR3 expression is recognized as a potential prognostic factor for patients with gastric cancer. In this study, we analyzed the prognostic significance of CXCR3 expression in gastric cancer. METHODS: We conducted a meta-analysis after selecting eligible studies through a literature search. We calculated pooled results to assess the associations between CXCR3 expression and overall survival (OS) and clinicopathological factors for gastric cancer. RESULTS: The pooled hazard ratio (HR) with 95% confidence interval (CI) between high expression of CXCR3 and OS was 0.46 (95% CI 0.30-0.71, P<0.001), suggesting that high expression of CXCR3 was associated with a favorable OS. High expression of CXCR3 was significantly correlated with younger age [odds ratio (OR) 0.67, 95% CI: 0.49-0.91, P=0.011], lower tumor grade (OR 0.46, 95% CI: 0.29-0.73, P=0.001), absence of lymph node metastasis (OR 0.47, 95% CI: 0.31-0.71, P<0.001), and lower Tumor-Node-Metastasis stage (OR 0.51, 95% CI: 0.35-0.74, P<0.001). CONCLUSIONS: High expression of CXCR3 was associated with better survival and may be a potential prognostic factor for patients with gastric cancer patients.
- All Author(s)
- H. M. Koh
; C. L. Hyun
; B. G. Jang
; H. J. Lee
- Issued Date
- 2021
- Type
- Article
- Keyword
- CXC chemokine receptor 3 (CXCR3); gastric cancer; meta-analysis; prognosis
- Publisher
- Society for Translational Cancer Research
- ISSN
- 2218-676X
; 2219-6803
- Citation Title
- Translational cancer research
- Citation Volume
- 10
- Citation Number
- 3
- Citation Start Page
- 1449
- Citation End Page
- 1456
- Language(ISO)
- eng
- DOI
- 10.21037/tcr-20-2862
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1923
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.