Plasma level of malondialdehyde in the cases of acute paraquat intoxication
- Abstract
- BACKGROUND, MATERIAL, AND METHODS: To assess plasma malondialdehyde (MDA) level as a clinical marker in acute paraquat (PQ) intoxication, we sequentially investigated 74 patients (40 males and 34 females, aged 49.9 +/- 16.2 years), all of whom ingested PQ as a means of suicide from July to December 2008. RESULTS: The baseline level of MDA (10.8 +/- 3.5 microM) had no correlation with plasma PQ levels of 22.1 +/- 48.7 microg/mL (median: 1.9, range <0.01-228.5) or with volume of PQ ingested. However, the following parameters were significantly different between survivors and nonsurvivors: the amount of PQ ingestion, plasma PQ levels, basal MDA levels, WBC, hemoglobin, hematocrit, platelet counts, albumin, BUN, creatinine, potassium, amylase, and arterial blood gas analysis (pH, pCO(2), HCO(-)(3)).The nonsurvivors' baseline MDA (11.4 +/- 3.8 vs. 9.8 +/- 2.8, p = 0.040) was higher than the survivors. However, the baseline level was not a predictor of mortality in the univariate and the multivariate binary logistic analyses. Among the patients whose MDA levels were measured sequentially, 58.3% of the patients (35 out of 60) showed fluctuating MDA levels, 25% (n = 15) showed steady decreases, with only 16.6% (n = 10) showing steady increases in MDA levels during the observation period. These findings imply the presence of active MDA metabolism and/or that the half-life of MDA is very short in the human body. CONCLUSION: Both cross-sectional and sequential measurements of plasma MDA do not provide reliable information on outcome in patients with acute PQ intoxication.
- All Author(s)
- H. W. Gil
; S. J. Seok
; D. S. Jeong
; J. O. Yang
; E. Y. Lee
; S. Y. Hong
- Issued Date
- 2010
- Type
- Article
- Keyword
- Paraquat; MDA; Clinical markers; Lipid peroxidation; ROS
- Publisher
- American Academy of Clinical Toxicology
European Association of Poisons Centres and Clinical Toxicologists
- ISSN
- 1556-3650
- Citation Title
- Clinical Toxicology
- Citation Volume
- 48
- Citation Number
- 2
- Citation Start Page
- 115
- Citation End Page
- 120
- Language(ISO)
- eng
- DOI
- 10.3109/15563650903468803
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1845
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