The clinical features of drug-induced liver injury observed through liver biopsy: focus on relevancy to autoimmune hepatitis
- Abstract
- BACKGROUND/AIMS: Accurate diagnosis of drug-induced liver injury (DILI) is difficult without considering the possibility of underlying diseases, especially autoimmune hepatitis (AIH). We investigated the clinical patterns in patients with a history of medication, liver-function abnormalities, and in whom liver biopsy was conducted, focusing on accompaniment by AIH. METHODS: The clinical, serologic, and histologic findings of 29 patients were compared and analyzed. The patients were aged 46.2±12.8 years (mean±SD), and 72.4% of patient were female. The most common symptom and causal drug were jaundice (58.6%) and herbal medications (55.2%), respectively. RESULTS: Aspartate aminotransferase (AST), alanine aminotransferase, total bilirubin, alkaline phosphatase, and γ-glutamyl transpeptidase levels were 662.2±574.8 U/L, 905.4±794.9 U/L, 12.9±10.8 mg/dL, 195.8±123.3 U/L, and 255.3±280.8 U/L, respectively. According to serologic and histologic findings, 21 cases were diagnosed with DILI and 8 with AIH. The AIH group exhibited significantly higher AST levels (537.1±519.1 vs. 1043.3±600.5 U/L), globulin levels (2.7±0.4 vs. 3.3±0.5 g/dL), and prothrombin time (12.9±2.4 vs. 15.2±3.9 s; P<0.05). Antinuclear antibody was positive in 7 of 21 cases of DILI and all 8 cases of AIH (P=0.002). The simplified AIH score was 3.7±0.9 in the DILI group and 6.5±0.9 in the AIH group (P<0.001). CONCLUSIONS: Accurate diagnosis is necessary for patients with a history of medication and visits for liver-function abnormalities; in particular, the possibility of AIH should be considered.
- All Author(s)
- H. Y. Ju
; J. Y. Jang
; S. W. Jeong
; S. A. Woo
; M. G. Kong
; H. Y. Jang
; S. H. Lee
; S. G. Kim
; S. W. Cha
; Y. S. Kim
; Y. D. Cho
; S. Y. Jin
; H. S. Kim
; B. S. Kim
- Issued Date
- 2012
- Type
- Article
- Keyword
- Drug-induced liver injury; Autoimmune hepatitis; Diagnosis
- Publisher
- 대한간학회
- ISSN
- 2287-2728
- Citation Title
- Clinical and Molecular Hepatology
- Citation Volume
- 18
- Citation Number
- 2
- Citation Start Page
- 213
- Citation End Page
- 218
- Language(ISO)
- eng
- DOI
- 10.3350/cmh.2012.18.2.213
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1802
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.