Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
- Abstract
- PURPOSE: Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Recently, the overexpression of programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) has been shown to correlate with poor prognosis in many cancers. However, the expression of PD-L1 or PD-1 ligand 2 (PD-L2) and clinical outcomes have not been fully investigated in HCC. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded samples were obtained from 85 patients with HCC who underwent surgery. The expression of PD-Ls (PD-L1, PD-L2) was evaluated by immunohistochemical analysis. RESULTS: The proportion of high expression groups of PD-L1 and PD-L2 was 27.1% and 23.5%, respectively. Univariate analysis revealed that tumor size (p < 0.001), histological differentiation (p=0.010), PD-L1 expression (p < 0.001), and PD-L2 expression (p=0.039) were significant prognostic factors of overall survival in patients with HCC. Multivariate analysis revealed that overall tumor size (hazard ratio [HR], 4.131; 95% confidence interval [CI], 2.233 to 7.643; p < 0.001 and HR, 3.455; 95% CI, 1.967 to 6.067; p < 0.001) and PD-L1 expression (HR, 5.172; 95% CI, 2.661 to 10.054; p < 0.001 and HR, 3.730; 95% CI, 1.453 to 9.574; p=0.006) were independent prognostic values for overall and disease-free survival. Patients with high expression of PD-Ls had a significantly poorer survival than those with low expression (p < 0.001, p=0.034). CONCLUSION: The overexpression of PD-Ls in HCC patients is correlated with survival and tumor recurrence. Further evaluation of PD-1 and PD-Ls as therapeutic targets and predictive biomarkers for HCC is warranted.
- All Author(s)
- H. I. Jung
; D. Jeong
; S. Ji
; T. S. Ahn
; S. H. Bae
; S. Chin
; J. C. Chung
; H. C. Kim
; M. S. Lee
; M. J. Baek
- Issued Date
- 2017
- Type
- Article
- Keyword
- Hepatocellular carcinoma; Programmed cell death 1; Programmed cell death 1 ligand; Prognosis
- Publisher
- 대한암학회
- ISSN
- 1598-2998
- Citation Title
- Cancer Research and Treatment
- Citation Volume
- 49
- Citation Number
- 1
- Citation Start Page
- 246
- Citation End Page
- 254
- Language(ISO)
- eng
- DOI
- 10.4143/crt.2016.066
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1717
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