궤양성 대장염에서 진단시기별 예후의 차이
- Alternative Title
- Differences in the Prognosis according to the Periods of Diagnosis in Ulcerative Colitis
- Abstract
- Background/Aims: Infliximab was approved for the treatment of ulcerative colitis (UC) in 2006 and has recently been used as rescue therapy in steroid-refractory UC. The aim of this study was to investigate the differences of medication use and prognosis in UC patients according to the periods of diagnosis.
Methods: From 1987 to 2012, a total of 1,422 patients with UC were retrospectively reviewed in 12 hospitals. The study population was divided into two groups according to the periods of diagnosis as follows; group A: 1987-2005, group B: 2006-2012. Analyzed variables were compared by using chi-square test and logistic regression analysis.
Results: Mean age of the subjects was 42.2 years, and the mean follow-up period was 4.7 years. In univariate analysis, the use of infliximab in group B was significantly higher than group A (4.5% vs. 7.6%, p=0.016), and UC-related hospitalization (45.8% vs. 40.1%, p=0.031) and UC-related surgery (6.4% vs. 3.5%, p=0.010) in group B was significantly lower than that of group A. The use of oral steroid in surgery group was significantly higher than non-surgery group in multivariate analysis (OR 1.85, 95% CI 1.03-3.30, p=0.039).
Conclusions: Infliximab might play an important role for the treatment of steroid-refractory UC. Well-designed prospective trials based on the efficacy and safety of infliximab are required in the future. (Korean J Gastroenterol 2014;64:93-97)
- All Author(s)
- H. B. Chae
; Y. S. Jung
; D. I. Park
; C. K. Lee
; K. C. Huh
; J. E. Shin
; J. H. Kim
; Y. S. Kim
; Y. Jung
; S. A. Jung
; H. J. Song
; H. J. Jang
; S. N. Hong
; Y.-H. Kim
- Issued Date
- 2014
- Type
- Article
- Keyword
- Ulcerative colitis; Infliximab; Steroid, refractory; Surgery
- Publisher
- 대한소화기학회
- ISSN
- 0301-2883
; 1598-9992
; 2233-6869
- Citation Title
- 대한소화기학회지
The Korean journal of gastroenterology
- Citation Volume
- 64
- Citation Number
- 2
- Citation Start Page
- 93
- Citation End Page
- 97
- Language(ISO)
- kor
- DOI
- 10.4166/kjg.2014.64.2.93
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1618
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