Efficacy of low-dose nebulized epinephrine as treatment for croup: A randomized, placebo-controlled, double-blind trial
- Abstract
- Objective: Croup treatment usually involves a single dose of systemic dexamethasone combined with nebulized epinephrine. However, the optimal dose of L-epinephrine remains unclear. We examined whether a low dose (0.1 mg/kg) was inferior to the conventional dose (0.5 mg/kg) of 1:1000 nebulized L-epinephrine in patients with moderate to severe croup. Methods: This randomized double-blind clinical non-inferiority trial was conducted in three pediatric emergency departments from May 2015 to October 2017. Children 6 months to 5 years old with moderate to severe croup (Westley scale scores 3-11) were eligible. Subjects were randomly assigned to the conventional dose (0.5 mg/kg: maximum 5 mg) or low dose (0.1 mg/kg; maximum 1 mg) group. All subjects received 0.6 mg/kg dexamethasone. Croup scores and other vital signs were measured before and at 30, 60, 90, and 120 min after nebulized L-epinephrine administration. The primary outcome was the change in croup score after 30 min. Results: The final analysis included 84 patients. The groups did not differ significantly in terms of demographic parameters. At 30 min after treatment with nebulized L-epinephrine, the croup scores in both groups were significantly reduced from the baseline values (p < 0.05) and did not differ between the two groups (p = 0.42). Neither blood pressure nor heart rate differed between the two groups. Conclusions: Low-dose 1:1000 L-epinephrine was not inferior in croup score reduction to the conventional dose in patients with moderate to severe croup. (C) 2019 Elsevier Inc. All rights reserved.
- All Author(s)
- J. H. Lee
; J. Y. Jung
; H. J. Lee
; D. K. Kim
; Y. H. Kwak
; I. Chang
; H. Kwon
; Y. J. Choi
; J. W. Park
; S. H. Paek
; J. H. Cho
- Issued Date
- 2019
- Type
- Article
- Keyword
- Pediatric; Croup; l-Epinephrine; Nebulizer
- ISSN
- 0735-6757
- Citation Title
- The American Journal of Emergency Medicine
- Citation Volume
- 37
- Citation Number
- 12
- Citation Start Page
- 2171
- Citation End Page
- 2176
- Language(ISO)
- eng
- DOI
- 10.1016/j.ajem.2019.03.012
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1334
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