Predictive Factors for Differentiating Between Crohn's Disease and Intestinal Tuberculosis in Koreans
- Abstract
- OBJECTIVES: A differential diagnosis between intestinal tuberculosis (ITB) and Crohn's disease (CD) is challenging. The aim of this study was to investigate the clinical, endoscopic, and histological features and to create a predictive score model for differentiating CD and ITB. METHODS: In total, 261 patients, 99 with ITB and 162 with CD, were recruited from seven tertiary centers from 2005 to 2013 and reviewed retrospectively. For the creation of a validated model, parameters were selected by univariate logistic regression and receiver operating characteristic curve analyses. Then, the prediction model was established on the basis of β-coefficients of the multivariate logistic regression. For the validation of the model, the same regression equation was tested on the other group. RESULTS: Age, diarrhea, ring-shaped ulcer, longitudinal ulcer, sigmoid involvement, suspicious radiological pulmonary tuberculosis, and gender were selected as the factors for a seven-marker model. In the seven-marker model of the validation data set, the sensitivity, specificity, positive predictive value, and negative predictive value with a cutoff level of 0.35 were 98.0, 92.4, 88.9, and 98.6, respectively. CONCLUSIONS: The seven-marker model seems to be highly reliable for differentiating between ITB and CD and could be conveniently used by clinicians to obtain results.
- All Author(s)
- Y. Jung
; Y. Hwangbo
; S. M. Yoon
; H. S. Koo
; H. D. Shin
; J. E. Shin
; H. S. Moon
; S. B. Kang
; J. R. Lee
; K. C. Huh
- Issued Date
- 2016
- Type
- Article
- Keyword
- Abdominal Pain/*etiology; Adolescent; Adult; Age Factors; Aged; Anus Diseases/*etiology; Colonoscopy; Crohn Disease/complications/*diagnosis/pathology; Diagnosis, Differential; Diarrhea/*etiology; Female; Humans; Logistic Models; Male; Middle Aged; ROC Curve; Radiography, Thoracic; Republic of Korea; Retrospective Studies; Sensitivity and Specificity; Sex Factors; Sigmoid Diseases/*etiology; Tuberculosis, Gastrointestinal/complications/*diagnosis/pathology; Tuberculosis, Pulmonary/complications/*diagnostic imaging; Ulcer/etiology/*pathology; Young Adult
- Publisher
- American College of Gastroenterology
National Gastroenterological Association
- ISSN
- 0002-9270
- Citation Title
- The American Journal of Gastroenterology
- Citation Volume
- 111
- Citation Number
- 8
- Citation Start Page
- 1156
- Citation End Page
- 1164
- Language(ISO)
- eng
- DOI
- 10.1038/ajg.2016.212
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1190
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