Availability of intravenous lipid emulsion therapy on endosulfan-induced cardiovascular collapse
- Abstract
- Acute Endosulfan poisoning is associated with a high mortality rate in humans, and can exceed 30% [Moon JM, Chun BJ. Acute endosulfan poisoning: a retrospective study. Hum Exp Toxicol 2009;28:309-16]. Prophylactic anticonvulsant therapy for symptomatic patients and aggressive treatment for seizures may limit morbidity, but, no effective antidote is available [Moses V, Peter JV. Acute intentional toxicity: endosulfan and other organochlorines. Clin Toxicol (Phila) 2010;48:539-44]. However, endosulfan poisoning is often completely reversible with the appropriate management [Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases. Singapore Med J 2006;47:1030-2]. Intravenous lipid emulsion (ILE) may be a useful in treatment of lipophilic medication overdoses as an adjunct to antidotal therapy [Rothschild L, Berns S, Oswald S, et al. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med 2010;18:51]. We believe that this is its first reported use in endosulfan toxicity.
- All Author(s)
- H. J. Moon
; J. W. Lee
- Issued Date
- 2013
- Type
- Article
- Keyword
- Endosulfan/*poisoning; Fat Emulsions, Intravenous/*therapeutic use; Fatal Outcome; Female; Heart Arrest/chemically induced/*therapy; Humans; Insecticides/*poisoning; Middle Aged; Suicide
- Publisher
- Elsevier
- ISSN
- 0735-6757
- Citation Title
- The American Journal of Emergency Medicine
- Citation Volume
- 31
- Citation Number
- 5
- Citation Start Page
- 886e.1
- Citation End Page
- 88600
- Language(ISO)
- eng
- DOI
- 10.1016/j.ajem.2012.10.006
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1184
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