Anti-heparin-platelet factor 4 antibody is a risk factor for vascular access obstruction in patients undergoing hemodialysis
- Abstract
- Since heparin is an anticoagulant commonly used in hemodialysis and the patients on hemodialysis are repeatedly exposed to heparin, heparin may be the cause of the development of heparin-dependent antibodies and thrombotic complications in patients on hemodialysis. The purpose of this study was to determine the prevalence and the clinical significance of the antibodies against heparin-platelet factor 4 complexes as determined by enzyme immunoassay in patients on maintenance hemodialysis. The prevalence of anti-heparin-platelet factor 4 antibodies was higher in hemodialysis patients than in normal subjects (8.8 vs 0.0%, p<0.05). The number of past episodes of vascular access obstruction per year was significantly higher in the anti-heparin-platelet factor 4 antibody positive group than antibody negative group. Anti-heparin-platelet factor 4 antibody positive patients experienced more frequent vascular access obstructions than control subjects. In conclusion, anti-heparin-platelet factor 4 antibody might be a risk factor for vascular access obstructions in patients with end-stage renal disease on maintenance hemodialysis.
- All Author(s)
- E. Y. Lee
; K. Y. Hwang
; J. O. Yang
; S. Y. Hong
- Issued Date
- 2003
- Type
- Article
- Keyword
- Anti-Heparin-Platelet Factor 4 Antibody; Renal Dialysis; Vascular Access Obstruction; Kidney Failure; Chronic
- Publisher
- 대한의학회
- ISSN
- 1011-8934
- Citation Title
- Journal of Korean Medical Science
- Citation Volume
- 18
- Citation Number
- 1
- Citation Start Page
- 69
- Citation End Page
- 72
- Language(ISO)
- eng
- DOI
- 10.3346/jkms.2003.18.1.69
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1096
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.