당뇨병성 신증에서 angiopoietins 유전자의 변화
- Alternative Title
- Angiopoietins in Diabetic Nephropathy
- Abstract
- PURPOSE: It has been reported that angiopoietins and Tie-2 receptor play an important role in the maintenance of glomerular filtration barrier in various glomerulonephritis models. We studied the role of angiopoietins on renal injury in diabetes. METHODS: In this study, we examined the changes of angiopoietin-1, angiopoietin-2, Tie-2 receptor, and nephrin expression in the experimental diabetic nephropathy and also determined whether these changes were modified by renoprotective intervention by angiotensin II receptor blocker, alpha-lipoic acid, and peroxisome proliferator activated receptor (PPAR)-agonist. RESULTS: A marked increase in urinary albumin excretion and glomerular volume was observed in diabetic rats. Renal angiopoietin-2 and Tie-2 receptor expression were significantly higher in diabetic rats than in the control groups, with a significant reduction in renal angiopoietin-2 expression, albuminuria, and renal hypertrophy in angiotensin II receptor blocker-treated diabetic rats. And there was a significant reduction in renal Tie-2 expression and renal hypertrophy in alpha-lipoic acid-treated and PPAR-gamma agonist-treated diabetic rats. CONCLUSION: These results demonstrate that the dysregulation of angiopoietins and Tie-2 receptor can lead to renal hypertrophy and albuminuria. Angiotensin II receptor blocker, alpha-lipoic acid, and PPAR-gamma agonist attenuated these changes in angiopoietins and/or Tie-2 expression and prevented the development of albuminuria and renal hypertrophy in vivo.
- All Author(s)
- E. Y. Lee
; H. W. Gil
; J. O. Yang
; J. H. Koh
; C. H. Chung
; S. Y. Hong
- Issued Date
- 2007
- Type
- Article
- Keyword
- Angiopoietin-1; Angiopoietin-2; Diabetic nephropathy; Nephrin; Tie-2 receptor
- Publisher
- 대한신장학회
- ISSN
- 1975-9460
- Citation Title
- The Korean Journal of Nephrology
- Citation Volume
- 26
- Citation Number
- 3
- Citation Start Page
- 311
- Citation End Page
- 319
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1091
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