혈액투석으로 성공적으로 치료한 메포르민 유산산증 2예
- Alternative Title
- Two Cases of Metformin-Induced Lactic Acidosis Successfully Treated by Hemodialysis
- Abstract
- Metformin-induced lactic acidosis is a rare life-threatening complication associated with metformin treatment and has a high mortality rate. Here, two cases of metformin-induced lactic acidosis are reported. A 22-year-old woman was admitted to our hospital with a metformin overdose (25 g) and lactic acidosis. Hemodialysis was initiated to correct the acidemia, and the patient showed full recovery. Her serum creatinine level returned to normal. A 50-year-old man presented with a 5-day history of muscle weakness. His medical history included diabetes mellitus for 6 years treated with metformin at 3,000 mg/day and hypertension. An arterial blood sample showed metabolic acidosis, with a venous lactate level of 31.1 mg/dL. The patient recovered fully after treatment with bicarbonate dialysis. These cases illustrate that the presence of clinical conditions such as renal failure increase the risk of metformin-induced lactic acidosis. Prompt recognition of lactic acidosis and early treatment with bicarbonate dialysis can result in a successful clinical outcome.
- All Author(s)
- B. I. Kang
; S. J. Kim
; J. H. Kim
; H. W. Gil
; J. O. Yang
; E. Y. Lee
; S. Y. Hong
- Issued Date
- 2011
- Type
- Article
- Keyword
- Metformin; Acidosis, Lactic; Renal dialysis
- Publisher
- 대한내과학회
- ISSN
- 1738-9364
; 2289-0769
- Citation Title
- 대한내과학회지
Korean Journal of Medidine
- Citation Volume
- 80
- Citation Number
- 4
- Citation Start Page
- 473
- Citation End Page
- 476
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1056
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