Browsing "병리과" by 키워드
전체 결과 621건 중 61-120 번을 표시중입니다.
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augmentation
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Autoantibodies
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Autoimmune disease
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Autophagy
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Background/aim: Deubiquitinating enzyme 3 (DUB3) is a member of the ubiquitin-specific proteases family involved in regulating cell proliferation, invasion, and apoptosis. However, the biological role and clinicopathological significance of DUB3 expression have not been elucidated in non-small cell lung cancer (NSCLC).
Patients and methods: We evaluated the expression of DUB3 by immunohistochemistry using tissue microarrays and assessed the clinicopathologic significance of DUB3 expression levels in 187 patients with NSCLC, including its two major subtypes (93 cases of adenocarcinoma and 72 cases of squamous cell carcinoma).
Results: In adenocarcinoma, we observed that DUB3 expression had an effect on tumor size (p=0.030), vessel invasion (p=0.038), T stage (p=0.014), and tumor recurrence (p=0.002). Kaplan-Meier curves with log-rank test showed that high DUB3 expression was correlated with significantly more favorable clinical outcomes compared to those of the low expression group in adenocarcinoma (p=0.013). Multivariate analysis of disease-free survival also demonstrated that DUB3 expression is an independent prognostic factor in lung adenocarcinoma (p=0.017). Additionally, we identified the correlation between DUB3 and the expression of large tumor suppressor kinase 1 expression, a core protein of the Hippo pathway.
Conclusion: DUB3 could function as a tumor suppressor by regulating the Hippo pathway in lung adenocarcinoma and can be considered a powerful predictive factor and therapeutic target.
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bcl-2
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Bcl2
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Benign
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beta-human chorionic gonadotropin
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Biliary dilation
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Biliary drainage
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Biliary stricture
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biological agent
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biomarker
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Biomarkers, Tumor/genetics
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Biopsy
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biopsy
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Blastoid
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Bone marrow
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bone marrow
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BRAF
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Branchial region
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Breast
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Breast cancer
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breast cancer
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Breast neoplasms
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Bronchial leiomyoma
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Bronchial neoplasms
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Bronchogenic cyst
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Broncholithiasis
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Bronchus
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Brunner’s gland hamartoma
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Brush cytology
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buccal fat pad
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Caco-2 Cells
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Calcification
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Calcium Phosphates/*chemistry
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Cancer
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cancer
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Carcinoma, non-small cell lung
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Carcinoma, non-small-cell
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Carcinoma, Papillary/diagnosis/*genetics
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Carcinoma, renal cell
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Carcinosarcoma
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Case report
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case report
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Castleman's disease
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Catamenial pneumothorax
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Cavernous hemangioma
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CCL2
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CCR2
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CD109
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CD90
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Cell Line, Tumor
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Cell Movement/genetics
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Cell Proliferation/genetics
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Cell-block
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cerebrospinal fluid
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cervical intraepithelial neoplasia
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cervix
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