소아에서 human metapneumovirus 감염
- Alternative Title
- Human metapneumovirus infection in Korean children
- Abstract
- Purpose : Human metapneumovirus(hMPV) is a respiratory viral pathogen that causes a wide spectrum of illnesses, ranging from asymptomatic infection to severe bronchiolitis. The virus has been identified world widely, but so far it has not been published in Korea. Methods : We obtained clinical samples by nasopharyngeal aspiration from 218 children hospitalized due to acute lower respiratory tract infections at Soonchunhyang University Hospital in Cheonan from October, 2004 to April, 2005. We designed specific primers from conserved region of fusion glycoprotein of hMPV. Total RNA was extracted and RT-PCR was performed, and single specific 423 bp product was obtained. The PCR product was confirmed to be fusion glycoprotein RNA by sequencing. Results : We detected hMPV in 15(6.9 percent) of the 218 hospitalized children. The infected children comprised nine boys and six girls; their mean age was 2.8 years(5 mo-12 yrs) and they were diagnosed with pneumonia(60 percent), bronchiolitis(33.3 percent), croup(6.6 percent). The number of cases of detected hMPV in Korea increased dramatically during the period from March to May 2005. Conclusion : hMPV is circulating in Korean children and is associated with respiratory tract infection. Additional studies are required to define the epidemiology and the extent of diseases in the general population caused by hMPV.
- All Author(s)
- 염희현
; 박준수
; 정동준
; 김창진
; 김용배
; 이대훈
; 김경중
; 천종윤
; 강천
; 정윤석
; 정향민
- Issued Date
- 2006
- Type
- Article
- Keyword
- Metapneumovirus; Respiratory tract infection; Korea; Child
- Publisher
- 대한소아과학회
- ISSN
- 0560-3560
; 1738-1061
; 2092-7258
; 2713-4148
- Citation Title
- Korean Journal of Pediatrics
- Citation Volume
- 49
- Citation Number
- 4
- Citation Start Page
- 401
- Citation End Page
- 409
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr//handle/2022.oak/402
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