http://schca-ir.schmc.ac.kr/handle/2022.oak/176 2026-10-22T20:59:33Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4928 Title: SPECT Cerebral Perfusion Patterns in Isolated Cervical Dystonia All Author(s): Byungseok Kim; Ik-Dong Yoo; Hyeonseok S Jeong; Yong-An Chung; In-Uk Song Abstract: Background and purpose: Isolated cervical dystonia is characterized by sustained or intermittent neck movements caused by involuntary muscle contractions, resulting in abnormal movements or postures of cervical areas. We measured altered regional cerebral blood flow (rCBF) in patients with idiopathic cervical dystonia compared to healthy controls and explored the correlation between dystonia severity and rCBF patterns. Methods: A total of 38 patients with isolated cervical dystonia and 29 healthy controls were recruited. All subjects underwent Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and Tc-99m HMPAO SPECT; TWSTRS was used to assess the severity of dystonia. rCBF was compared between groups using voxel-wise statistical analyses. Associations between rCBF in significant clusters and TWSTRS scores were examined using linear regression. Results: Compared with controls, patients with cervical dystonia exhibited reduced rCBF in brain regions implicated in sensory processing, motor control, and higher cognitive functions, including the left middle temporal gyrus, right postcentral gyrus, right lingual gyrus, left precuneus, right temporal pole, right middle cingulate gyrus, and right anterior cingulate gyrus. Although reduced rCBF was observed in seven regions, only the right temporal pole showed a significant correlation with TWSTRS motor scores. Reduced rCBF in the right temporal pole negatively correlated with higher TWSTRS scores in dystonia patients. Conclusion: The negative correlation between reduced rCBF in the right temporal pole and increased TWSTRS scores highlights a potential association between altered cerebral perfusion and dystonic symptom severity. Understanding these alterations could offer insights into the neurobiological basis of cervical dystonia, aiding targeted therapeutic interventions. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4879 Title: Association of loss of visceral adipose tissue after concurrent chemoradiotherapy with poor survival in patients with head and neck squamous cell carcinoma All Author(s): Sang Mi Lee; In Young Jo; Jae Hong Park; Min-Su Kim; Hye Jeong Choi; Jeong Won Lee; Su Jin Jang Abstract: Objectives: Nutritional status is known to be associated with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients. The aim of this study was to investigate whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue mass after concurrent chemoradiotherapy (CCRT) are significantly related to progression-free survival (PFS) and overall survival (OS) in HNSCC patients. Methods: 117 HNSCC patients who underwent definitive CCRT were retrospecitively analyzed. Using unenhanced computed tomography images from pretreatment (PET1) and 3 months post-CCRT (PET2) F-18 fluorodeoxyglucose positron emission tomography (PET)/computed tomography scans, we measured the cross-sectional areas of SAT and VAT. The areas of SAT and VAT were adjusted for height squared to calculate the SAT and VAT indices. Results: Following CCRT, 92 patients (78.6%) exhibited a decrease in VAT index values. The complete metabolic response (CMR) patient group showed significantly higher values of VAT index at PET2 compared to the non-CMR group (P < 0.05). Multivariate survival analysis found that the VAT index at PET2 and the percent changes in both the SAT index and VAT index were significant predictors for both PFS and OS (P < 0.05). Patients with a low VAT index at PET2 and marked losses of SAT index and VAT index after CCRT had poorer survival outcomes. On subgroup survival analysis, the percent change in VAT index was a significant predictor for PFS and OS in both CMR and non-CMR groups (P < 0.05). Conclusions: The alteration in VAT mass after CCRT was clinically significant for risk stratification of survival outcomes in HNSCC patients. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4872 Title: Association of quantitative growth plate uptake parameters on bone scintigraphy with growth velocity in children All Author(s): Ki Jin Jung; Sun-Pyo Hong; Ik Dong Yoo; Sang Mi Lee; Jeong Won Lee Abstract: Objective: The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children. Methods: We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GPmax/D) and mean growth plate uptake to mean diaphyseal uptake (GPmean/D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GPmax/D parameters and eight GPmean/D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed. Results: Correlation analysis with growth velocity revealed that the anterior GPmax/D (numerical mean of GPmax/D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters (P = 0.034). The anterior GPmax/D also demonstrated a significant negative correlation with age (P = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GPmean/D (geometric mean of GPmean/D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GPmax/D (0.734). Conclusion: Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4856 Title: Prognostic Significance of Volumetric Parameters on Pretreatment FDG PET/CT in Patients With Hepatocellular Carcinoma Receiving Atezolizumab Plus Bevacizumab Therapy All Author(s): Jeong Won Lee; Sang Mi Lee; Beodeul Kang; Jung Sun Kim; Chansik An; Hong Jae Chon; Su Jin Jang Abstract: Background: This study aimed to assess prognostic significance of FDG PET/CT parameters in predicting progression-free survival (PFS) and overall survival (OS) in patients with hepatocellular carcinoma (HCC) treated with atezolizumab plus bevacizumab therapy. Patients and methods: We retrospectively enrolled 78 patients with HCC who underwent FDG PET/CT before atezolizumab plus bevacizumab therapy and identified intrahepatic target tumor lesions on pretreatment imaging studies. From PET/CT images, we measured SUVmax, tumor-to-normal liver uptake ratio, metabolic tumor volume, and total lesion glycolysis (TLG) for intrahepatic tumor lesions, as well as SUVmax for extrahepatic metastatic lesions (extrahepatic SUVmax). Results: In comparisons of PET/CT parameters, patients with progressive disease demonstrated significantly higher TLG values than those achieving complete or partial response ( P < 0.05). In the multivariate survival analysis, TLG independently predicted both PFS ( P = 0.019) and OS ( P = 0.003). Metabolic tumor volume was significantly associated with OS alone ( P = 0.010), and extrahepatic SUVmax was significantly associated with only PFS ( P = 0.045). Patients with high TLG values experienced poorer PFS and OS than those with low TLG values ( P < 0.05). Conclusions: TLG in intrahepatic HCC lesions was significantly associated with treatment response and served as an independent prognostic factor for PFS and OS. TLG could be a potential imaging biomarker for predicting clinical outcomes in patients with HCC receiving atezolizumab plus bevacizumab therapy. 2024-12-31T15:00:00Z