http://schca-ir.schmc.ac.kr/handle/2022.oak/135 2026-11-15T13:48:16Z 2026-11-15T13:48:16Z Ji Won Kim Bon Seok Koo Han Su Kim Jae Hong Park Jung Je Park Jun-Ook Park Jun Girl Seok Kyoung-Ho Oh Seung Hoon Woo Young-Gyu Eun Yoon Se Lee Man Ki Chung Woo-Jin Jeong Eun-Jae Chung Yong Bae Ji Su-Yeon Yu Soo Hyun Lee Sei Young Lee Kwang-Jae Cho http://schca-ir.schmc.ac.kr/handle/2022.oak/5044 2026-10-28T02:26:44Z 2024-12-31T15:00:00Z

Title: Quality of Life in Oropharyngeal Cancer: A Retrospective Analysis of Patient Characteristics and Treatment Modalities All Author(s): Ji Won Kim; Bon Seok Koo; Han Su Kim; Jae Hong Park; Jung Je Park; Jun-Ook Park; Jun Girl Seok; Kyoung-Ho Oh; Seung Hoon Woo; Young-Gyu Eun; Yoon Se Lee; Man Ki Chung; Woo-Jin Jeong; Eun-Jae Chung; Yong Bae Ji; Su-Yeon Yu; Soo Hyun Lee; Sei Young Lee; Kwang-Jae Cho Abstract: Background: In patients with oropharyngeal squamous cell carcinoma (OPSCC), understanding the factors affecting post-treatment quality of life (QoL) is essential for optimizing long-term management. This study aimed to evaluate the impact of patient characteristics and treatment modalities on post-treatment QoL in patients with OPSCC. Patients and methods: A total of 303 patients with OPSCC who completed treatment were assessed for QoL between August 2023 and January 2024 using various validated questionnaires. In addition, patient charts were reviewed. Results: Lower QoL was associated with older age, female sex, lower education, reduced income, fewer household members, unemployment, less than 5 years since diagnosis, advanced stage, disease recurrence, and human papillomavirus (HPV)-negative status. Robotic surgery and surgery alone were associated with better QoL than conventional surgery or surgery with adjuvant therapy. Radiotherapy is associated with additional issues, such as dry mouth and sticky saliva. Fewer patients who underwent surgery with adjuvant therapy reported tooth and dry mouth issues than those who received definitive chemoradiotherapy. In subgroup analyses, QoL in HPV-positive patients mirrored that of the overall cohort, whereas no significant differences were noted between treatment modalities in HPV-negative patients. Similarly, in the early stage group, HPV-positive patients had better QoL than HPV-negative patients; however, no significant differences were observed on the basis of HPV status or treatment modality in advanced-stage patients. Conclusions: Sociodemographic factors, clinicopathological characteristics, and treatment modalities significantly impacted the post-treatment QoL of patients with OPSCC. Individualized treatment planning and comprehensive post-treatment care are crucial for optimizing QoL, particularly in patients at higher risk of poorer outcomes.

2024-12-31T15:00:00Z Juyeon Kim Gyo Jeong Gu Sung Sik Hur Min-Kyu Kim Fenny Soetanto Jiwon Son Joo Hyun Kim Taewan Kim Yun Kyung Lee Jaemoon Yang Hyung Kwon Byeon Jong Eun Lee Sun Wook Han Sung Yong Kim Jun-Hee Lee Ju Hun Lee Myung Jin Ban Yongsung Hwang http://schca-ir.schmc.ac.kr/handle/2022.oak/5040 2026-10-28T02:26:43Z 2024-12-31T15:00:00Z

Title: Cell surface engineering for inhibition of breast cancer cell motility through modulation of mechanotransduction and focal adhesion dynamics All Author(s): Juyeon Kim; Gyo Jeong Gu; Sung Sik Hur; Min-Kyu Kim; Fenny Soetanto; Jiwon Son; Joo Hyun Kim; Taewan Kim; Yun Kyung Lee; Jaemoon Yang; Hyung Kwon Byeon; Jong Eun Lee; Sun Wook Han; Sung Yong Kim; Jun-Hee Lee; Ju Hun Lee; Myung Jin Ban; Yongsung Hwang Abstract: Metastasis is a leading cause of mortality in breast cancer and is critically influenced by cell-extracellular matrix (ECM) interactions, mechanical forces, and cellular motility. In this study, we present a cell surface engineering approach using tris(2-carboxyethyl)phosphine (TCEP), a biocompatible thiol-modifying agent, to modulate the biomechanical behavior of breast cancer cells. TCEP treatment increased surface thiol availability, enhanced phosphorylation of focal adhesion kinase (FAK), and promoted the elongation of pFAK-positive focal adhesions, along with cytoskeletal remodeling and stronger cell-ECM adhesion. These molecular and structural changes corresponded with significantly reduced migration and invasion of MCF7 and MDA-MB-231 cells. Using traction force microscopy (TFM), we further observed increased intracellular tension and traction stress, providing quantitative insight into how surface modification regulates mechanotransduction. These findings highlight the potential of cell surface thiol engineering to control cancer cell adhesion and motility, providing a platform for future identification of clinically applicable redox-modulating agents.

2024-12-31T15:00:00Z Ji Won Kim Bon Seok Koo Han Su Kim Jae Hong Park Jung Je Park Jun-Ook Park Jun Girl Seok Kyoung-Ho Oh Seung Hoon Woo Young-Gyu Eun Yoon Se Lee Man Ki Chung Woo-Jin Jeong Eun-Jae Chung Yong Bae Ji Su-Yeon Yu Soo Hyun Lee Sei Young Lee Kwang-Jae Cho http://schca-ir.schmc.ac.kr/handle/2022.oak/5043 2026-10-28T02:26:44Z 2025-12-31T15:00:00Z

Title: ASO Visual Abstract: Quality of Life in Oropharyngeal Cancer-A Retrospective Analysis of Patient Characteristics and Treatment Modalities All Author(s): Ji Won Kim; Bon Seok Koo; Han Su Kim; Jae Hong Park; Jung Je Park; Jun-Ook Park; Jun Girl Seok; Kyoung-Ho Oh; Seung Hoon Woo; Young-Gyu Eun; Yoon Se Lee; Man Ki Chung; Woo-Jin Jeong; Eun-Jae Chung; Yong Bae Ji; Su-Yeon Yu; Soo Hyun Lee; Sei Young Lee; Kwang-Jae Cho

2025-12-31T15:00:00Z Yun Jin Kang Gulnaz Stybayeva Se Hwan Hwang http://schca-ir.schmc.ac.kr/handle/2022.oak/5036 2026-10-28T02:26:42Z 2023-12-31T15:00:00Z

Title: Effect of the BiZact™ Low-Temperature Dissecting Device on Intra- and Postoperative Morbidities Related to Tonsillectomy-A Systematic Review and Meta-Analysis All Author(s): Yun Jin Kang; Gulnaz Stybayeva; Se Hwan Hwang Abstract: Background and Objectives: We investigated the effects of using a BiZact™ device for tonsillectomy on operating time, intraoperative blood loss, postoperative bleeding rate, and pain through a meta-analysis of the relevant literature. Materials and Methods: We reviewed studies retrieved from the databases of PubMed, SCOPUS, Google Scholar, Embase, Web of Science, and Cochrane up to March 2024. The results were analyzed following PRISMA guidelines. Six studies that compared the outcomes of patients receiving perioperative BiZact™ tonsillectomy with those in control groups (cold steel dissection or bipolar tonsillectomy) were included for this analysis of the outcomes, which included intraoperative bleeding and time, postoperative pain, and frequency of postoperative bleeding. Results: The operative time (SMD -11.5985, 95%CI [-20.3326; -2.8644], I2 = 99.5%) in the treatment group was significantly reduced compared to the control group. However, BiZact™ showed no significant efficacy in reducing intraoperative bleeding when compared with the control group (SMD -0.0480, 95%CI [-1.8200; 1.7240], I2 = 98.6%). Postoperative pain on day 1 (SMD -0.0885, 95%CI [-0.4368; 0.2598], I2 = 98.9%), day 3 (SMD -0.2118, 95%CI [-0.6110; 0.1873], I2 = 99.5%), and later than day 7 (SMD 0.0924, 95%CI [-0.2491; 0.4338], I2 = 98.6%) in the treatment group was not significantly reduced relative to the control group. When compared to the control group, BiZact™ did not reduce the incidence of secondary postoperative bleeding control in the operation room (OR 0.5711, 95%CI [0.2476; 1.3173], I2 = 32.1%), primary bleeding (OR 0.4514, 95%CI [0.0568; 3.5894], I2 = 0.0%), or all postoperative bleeding events (OR 0.8117, 95%CI [0.5796; 1.1368], I2 = 26.3%). Conclusions: This study demonstrated that using the BiZact™ device for tonsillectomy significantly decreased the operative time but could not effectively reduce intraoperative bleeding or postoperative pain and bleeding.

2023-12-31T15:00:00Z